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Editorials

Networks for Africa p395

The future of science and technology in Africa depends on the development of mutually supportive networks. Two examples show how imaginative initiatives can be turned into models for others.

doi:10.1038/435395a


The heat is on p396

A successor to the Kyoto Protocol on climate change must involve mandatory emissions caps.

doi:10.1038/435396a


Life is what you make it p396

This issue celebrates the emerging field of synthetic biology.

doi:10.1038/435396b


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Research Highlights

Research highlights p398

doi:10.1038/438398a


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News

Google makes data free for all p400

Project could lead to more 'intelligent' web pages.

Declan Butler

doi:10.1038/438400a


US watchdog finds bias against morning-after pill p401

Drug agency accused of mixing politics with science.

Meredith Wadman

doi:10.1038/438401a


Sidelines p402

doi:10.1038/438402a


Neuroscientists put gene therapy into reverse p402

Making the disease could break the disease.

Jim Giles

doi:10.1038/438402b


Seals net data from cold seas p402

Tagged animals to be used as remote sensors.

Tom Simonite

doi:10.1038/438402c


Korean stem-cell crisis deepens p405

Fertility specialist admits buying human eggs.

David Cyranoski

doi:10.1038/438405a


Deal on toxicity law fails to appease p406

EU draws up compromise for chemical-safety legislation.

Alison Abbott

doi:10.1038/438406a


China steps up drive to vaccinate all domestic birds p406

Officials claim 8 billion birds inoculated so far.

David Cyranoski

doi:10.1038/438406b


Software shakes up schizophrenia diagnosis p407

Brain scan analysis could reveal disease before symptoms.

Jennifer Wild

doi:10.1038/438407a


News in brief p409

doi:10.1038/438409a


Correction p409

doi:10.1038/438409b


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News Features

Energy in California: Power struggle p410

For decades, California has bucked the US trend of gobbling ever more electricity. But can the state pull off an even more ambitious goal and slash its greenhouse-gas emissions? Charles Petit finds out.

doi:10.1038/438410a


Antarctic astronomy: Seeing in the dark p414

When darkness falls for Antarctica's long winter months, the sky becomes a spectacular canopy of stars. At one brand new base, astronomers are braving the extreme cold to build telescopes that they hope will rival space observatories. Gabrielle Walker investigates.

doi:10.1038/438414a

See also: Editor's summary


Synthetic biology: Designs on life p417

Earlier this month, students from around the world locked horns in competition. Their challenge was to build functioning devices out of biological parts. Erika Check finds out how they got on.

doi:10.1038/438417a


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Business

Property rights go East p420

China's approach to patents is undergoing a sharp transition, as David Cyranoski reports.

doi:10.1038/438420a


Market watch p421

Colin Macilwain

doi:10.1038/437421b


In brief p421

doi:10.1038/438421a


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Correspondence

Bush's policy stopped US gaining stem-cell lead p422

Robert Lanza and Ronald M. Green

doi:10.1038/438422a


Evidence of group learning does not add up to culture p422

William L. Abler

doi:10.1038/438422b


Is the ID debate proof of an intelligent deceiver? p422

A. Richard Palmer

doi:10.1038/438422c

See also: Editor's summary


Librarians can help prevent accidental plagiarism p422

Keith Nockels

doi:10.1038/438422d


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Commentary

Let us go forth and safely multiply p423

Synthetic biology, which involves the engineering of new biological components and organisms and the redesign of existing ones, will require community discipline and openness if it is to flourish safely, says George Church.

doi:10.1038/438423a

See also: Editor's summary


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Books and Arts

All the fun of the fare p425

A selection of amusing morsels from the history of nutrition science.

Marion Nestle reviews Terrors of the Table: The Curious History of Nutrition by Walter Gratzer

doi:10.1038/438425a


Unearthing mammalian origins p426

Timothy Rowe reviews Mammals From the Age of Dinosaurs: Origins, Evolution, and Structure by Zofia Kielan-Jaworowska, Richard L. Cifelli and Zhe-Xi Luo

doi:10.1038/438426a

See also: Editor's summary


A poisonous present p427

Benno Müller-Hill reviews Kampfstoff-Forschung im Nationalsozialismus: Zur Kooperation von Kaiser-Wilhelm-Instituten, Militär und Industrie [Weapons Research in National Socialism] by Florian Schmaltz

doi:10.1038/438427a


The latest on latex p427

Robert W. Cahn reviews Tears of the Tree: The Story of Rubber — A Modern Marvel by John Loadman

doi:10.1038/438427b


Installation: Uranium days p428

Sylvie Coyaud reviews The Children of Uranium

doi:10.1038/438428a


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Essay

Concept

Pushing for power p429

Tales of brilliant scientists and their heroic discoveries can overshadow the true nature of scientific communities, which are often dominated by battles for power and success.

Ad Lagendijk

doi:10.1038/438429a


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News and Views

Quantum computing: A bit chilly p431

A quantum computer needs a constant supply of 'qubits' in a known state. A nuclear magnetic resonance experiment that cools qubits by pumping entropy into a heat bath is a step closer to that goal.

Leonard J. Schulman

doi:10.1038/438431a

See also: Editor's summary


Cell biology: Silenced RNA on the move p432

Proteins are often produced at their site of action, but the RNAs from which they are made must be kept inactive until they reach the right spot. It seems this 'silencing' of RNA is linked to its transport around the cell.

Ralf Dahm and Michael Kiebler

doi:10.1038/438432a


50 & 100 years ago p433

doi:10.1038/438433a


Condensed-matter physics: Focus on the Fermi surface p435

The electrical resistance of some manganese oxides takes a tumble when they become magnetic. Close examination confirms the interplay of conduction electrons and lattice vibrations that contributes to this effect.

Peter Littlewood and S breveimon Kos

doi:10.1038/438435a

See also: Editor's summary


Photonics: Wingèd light p436

Amber Jenkins

doi:10.1038/438436a


Obesity: Aquaporin enters the picture p436

The aquaporins are membrane channels that were originally identified as regulators of a cell's water balance. A member of the aquaporin family is now implicated as a central agent in controlling fat metabolism.

Gema Frühbeck

doi:10.1038/438436b


Histocompatibility: Colonial match and mismatch p437

Distinguishing self from non-self is the underlying basis of immunity. Intriguingly, the genetic system that governs a natural process akin to tissue transplantation in vertebrates has been characterized in an invertebrate.

Gary W. Litman

doi:10.1038/438437a

See also: Editor's summary


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Brief Communications

Synthetic biology: Engineering Escherichia coli to see light p441

These smart bacteria 'photograph' a light pattern as a high-definition chemical image.

Anselm Levskaya, Aaron A. Chevalier, Jeffrey J. Tabor, Zachary Booth Simpson, Laura A. Lavery, Matthew Levy, Eric A. Davidson, Alexander Scouras, Andrew D. Ellington, Edward M. Marcotte and Christopher A. Voigt

doi:10.1038/nature04405

See also: Editor's summary


Insect communication: 'No entry' signal in ant foraging p442

Elva J. H. Robinson, Duncan E. Jackson, Mike Holcombe and Francis L. W. Ratnieks

doi:10.1038/438442a

See also: Editor's summary


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Brief Communications Arising

Immunology: Insulin auto-antigenicity in type 1 diabetes pE5

Darcy B. Wilson

doi:10.1038/nature04423


Immunology: Insulin auto-antigenicity in type 1 diabetes (Reply) pE5

David A. Hafler, Sally C. Kent, Yahua Chen, Lisa Bregoli, Sue M. Clemmings, Bernhard Hering, Norma Sue Kenyon and Camillo Ricordi

doi:10.1038/nature04424


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Reviews

Reconstruction of genetic circuits p443

David Sprinzak and Michael B. Elowitz

doi:10.1038/nature04335

See also: Editor's summary


Foundations for engineering biology p449

Drew Endy

doi:10.1038/nature04342

See also: Editor's summary | Authors


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Articles

Isolation and characterization of a protochordate histocompatibility locus p454

Anthony W. De Tomaso, Spencer V. Nyholm, Karla J. Palmeri, Katherine J. Ishizuka, William B. Ludington, Katrina Mitchel and Irving L. Weissman

doi:10.1038/nature04150

See also: Editor's summary | News and Views by Litman


Direct observation of base-pair stepping by RNA polymerase p460

Elio A. Abbondanzieri, William J. Greenleaf, Joshua W. Shaevitz, Robert Landick and Steven M. Block

doi:10.1038/nature04268

See also: Editor's summary


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Letters

Direct detection of a magnetic field in the innermost regions of an accretion disk p466

Jean-François Donati, Fréderic Paletou, Jérome Bouvier and Jonathan Ferreira

doi:10.1038/nature04253

See also: Editor's summary


Experimental implementation of heat-bath algorithmic cooling using solid-state nuclear magnetic resonance p470

J. Baugh, O. Moussa, C. A. Ryan, A. Nayak and R. Laflamme

doi:10.1038/nature04272

See also: Editor's summary | News and Views by Schulman


Nodal quasiparticle in pseudogapped colossal magnetoresistive manganites p474

N. Mannella, W. L. Yang, X. J. Zhou, H. Zheng, J. F. Mitchell, J. Zaanen, T. P. Devereaux, N. Nagaosa, Z. Hussain and Z.-X. Shen

doi:10.1038/nature04273

See also: Editor's summary | News and Views by Littlewood & Kos


Probing carrier dynamics in nanostructures by picosecond cathodoluminescence p479

M. Merano, S. Sonderegger, A. Crottini, S. Collin, P. Renucci, E. Pelucchi, A. Malko, M. H. Baier, E. Kapon, B. Deveaud and J.-D. Ganière

doi:10.1038/nature04298


Impacts of orbital forcing and atmospheric carbon dioxide on Miocene ice-sheet expansion p483

Ann Holbourn, Wolfgang Kuhnt, Michael Schulz and Helmut Erlenkeuser

doi:10.1038/nature04123

See also: Authors


Density of hydrous silicate melt at the conditions of Earth's deep upper mantle p488

Kyoko N. Matsukage, Zhicheng Jing and Shun-ichiro Karato

doi:10.1038/nature04241


The entomological inoculation rate and Plasmodium falciparum infection in African children p492

D. L. Smith, J. Dushoff, R. W. Snow and S. I. Hay

doi:10.1038/nature04024

See also: Editor's summary | Authors


Eye-specific effects of binocular rivalry in the human lateral geniculate nucleus p496

John-Dylan Haynes, Ralf Deichmann and Geraint Rees

doi:10.1038/nature04169

See also: Editor's summary


Neural measures reveal individual differences in controlling access to working memory p500

Edward K. Vogel, Andrew W. McCollough and Maro G. Machizawa

doi:10.1038/nature04171

See also: Editor's summary


Design principles of a bacterial signalling network p504

Markus Kollmann, Linda Løvdok, Kilian Bartholomé, Jens Timmer and Victor Sourjik

doi:10.1038/nature04228


The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation p508

Uttiya Basu, Jayanta Chaudhuri, Craig Alpert, Shilpee Dutt, Sheila Ranganath, Gang Li, Jason Patrick Schrum, John P. Manis and Frederick W. Alt

doi:10.1038/nature04255


Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1 p512

Stefan Hüttelmaier, Daniel Zenklusen, Marcell Lederer, Jason Dictenberg, Mike Lorenz, XiuHua Meng, Gary J. Bassell, John Condeelis and Robert H. Singer

doi:10.1038/nature04115

See also: News and Views by Dahm & Kiebler


Structures of ParB bound to DNA reveal mechanism of partition complex formation p516

Maria A. Schumacher and Barbara E. Funnell

doi:10.1038/nature04149


An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA p520

T. Martin Schmeing, Kevin S. Huang, Scott A. Strobel and Thomas A. Steitz

doi:10.1038/nature04152

See also: Editor's summary


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Naturejobs

Prospect

Turning the tables p525

It's time to make sure foreign students feel welcome.

Paul Smaglik

doi:10.1038/nj7067-525a


Special Report

Save the world and keep a career p526

If the prospect of endless lab work doesn't appeal, maybe using your qualifications to address global problems more directly would be the answer. There is plenty of scope for those who wish to pursue science with a 'social conscience', as Virginia Gewin finds out.

Virginia Gewin

doi:10.1038/nj7067-526a


Career Views

Richard Somiari, president and chief scientific officer, ITSI-Biosciences, Johnstown, Pennsylvania p528

Native Nigerian journeys from food technology to proteomics.

Corie Lok

doi:10.1038/nj7067-528a


Bricks & Mortar p528

University of Pittsburgh facility houses mix of departments and facilities.

Kendall Powell

doi:10.1038/nj7067-528b


Graduate Journal: Who needs evidence? p528

Pondering the 'benefits' of intelligent design.

Jason Underwood

doi:10.1038/nj7067-528c


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Futures

It never rains in VR p530

Where two worlds collide.

John Gilbey

doi:10.1038/438530a


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