Editorials

Will the regulator please stand up p257

It's time for the South Korean government to launch an investigation into how eggs were obtained for a ground-breaking stem-cell experiment.

doi:10.1038/438257a

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Heavy weather p257

Washington DC still doesn't seem to understand the threat posed by global warming.

doi:10.1038/438257b

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Pulling together p258

Protests by Chinese students at Yale University are highlighting strains on a symbiotic relationship.

doi:10.1038/438258a

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Research Highlights

Research highlights p260

doi:10.1038/438260a

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News

Stem-cell brothers divide p262

Famous co-authors part company over egg-donation controversy.

David Cyranoski and Erika Check

doi:10.1038/438262a

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Japan's embryo experts beg for faster ethical reviews p263

Researchers accuse review boards of holding them back.

David Cyranoski

doi:10.1038/438263a

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US budget yields scant research rises p264

NASA gets research boost as Congress passes fiscal plans.

Geoff Brumfiel and Tony Reichhardt

doi:10.1038/438264a

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Small conferences pay their way p264

Survey suggests it's good to talk.

Kendall Powell

doi:10.1038/438264b

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Day of judgement for intelligent design p267

Split decision across states signals no end to 'classroom creationism' debate.

Geoff Brumfiel

doi:10.1038/438267a

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Atomic agency launches bid to bank nuclear fuel p268

International supply of partly-enriched uranium could slow proliferation.

Jim Giles

doi:10.1038/438268a

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Scheme to track greenhouse gases takes to the air p268

Commercial aircraft is fitted with carbon dioxide detector.

Ichiko Fuyuno

doi:10.1038/438268b

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Sidelines p269

doi:10.1038/438269a

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News in brief p270

doi:10.1038/438270a

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News Features

Invasive species: Shoot to kill p272

The US government has adopted a tough approach to battling harmful exotic plants: specialist strike teams. But can they prevail? Emma Marris finds out it's not all black and white.

doi:10.1038/438272a

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Climate change: The long-range forecast p275

The Himalayas, roof of the world, are springing a leak. As the climate warms up, melting glaciers are threatening the livelihoods of millions. David Cyranoski reports.

doi:10.1038/438275a

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Chinese students in the US: Taking a stand p278

A protest by Chinese graduate students at Yale University has revealed the plight of a vulnerable workforce in US labs. Geoff Brumfiel investigates.

doi:10.1038/438278a

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Business

Wisdom of the crowd p281

Decision makers, wrestling with thorny choices, are tapping into the collective foresight of ordinary people. Jim Giles reports.

doi:10.1038/438281a

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Correspondence

Biodiversity: involvement of local people is crucial p282

Martyn G. Murray and Jacqueline A. Yelland

doi:10.1038/438282a

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Space triumph reveals new spirit of openness in China p282

Bin Wang

doi:10.1038/438282b

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Intelligent, social rat can find joy in a hostile world p282

Jonathan Balcombe

doi:10.1038/438282c

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Peer-review system could gain from author feedback p282

Alon Korngreen

doi:10.1038/438282d

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How Wallace and Dampier faced tsunamis at sea p282

Jeyaraney Kathirithamby

doi:10.1038/438282e

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Commentaries

Climate proofing the Netherlands p283

Regional climate change should not be seen only as a threat; changes to weather patterns could generate opportunities for large-scale innovations, say Pavel Kabat, Pier Vellinga and their colleagues.

doi:10.1038/438283a

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Policy needs robust climate science p285

The path between climate science and policy is not always linear, argue Aristides Patrinos and Anjuli Bamzai.

doi:10.1038/438285a

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Books and Arts

The origins of darwinism p287

Impending anniversaries and the trial over 'intelligent design' make this a good time to revisit Darwin.

Bruce H. Weber reviews From So Simple a Beginning: The Four Great Books of Charles Darwin and Darwin: The Indelible Stamp

doi:10.1038/438287a

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Dancing to Darwin's tune p288

W. Tecumseh Fitch reviews The Singing Neanderthals: The Origins of Music, Language, Mind and Body by Steve Mithen

doi:10.1038/438288a

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Darwin in fiction p288

Darwin's life and work has also inspired two recent novels.

doi:10.1038/438288b

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Science in culture: Monkey business p289

Charles Darwin changed the way animals were viewed in art.

Colin Martin

doi:10.1038/438289a

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Essay

A polymath's dilemma p291

Thomas Young strove to satisfy his curiosity in virtually every scientific subject and, undeterred by sceptics calling for a narrower focus, made discoveries in almost all the fields he studied.

Andrew Robinson

doi:10.1038/438291a

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News and Views

Epidemiology: Dimensions of superspreading p293

Analyses of contact-tracing data on the spread of infectious disease, combined with mathematical models, show that control measures require better knowledge of variability in individual infectiousness.

Alison P. Galvani and Robert M. May

doi:10.1038/438293a

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Nano-Optics: Gold loses its lustre p295

The perfect lens would immaculately reproduce an image of an object, with no light losses in the transition. The strange optical properties of a gold nanostructure bring the prospect of such a component into sharper focus.

Roy Sambles

doi:10.1038/438295a

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Palaeontology: Data on a plate p296

Henry Gee

doi:10.1038/438296a

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Developmental biology: The X-inactivation yo-yo p297

In female mammals, one of two X chromosomes has to be shut down during early development. To what extent does this 'imprinted X-chromosome inactivation' involve the history of the chromosome?

Wolf Reik and Anne C. Ferguson-Smith

doi:10.1038/438297a

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50 & 100 years ago p298

doi:10.1038/438298a

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Communications technology: Chaos down the line p298

Chaos, goes conventional wisdom, can only be a malign influence in telecommunications. But a technique that uses chaotically varying signals to transmit information more privately may help it shed that bad-boy image.

Rajarshi Roy

doi:10.1038/438298b

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Cell biology: Two pores better than one? p299

The movement of proteins through a cell's membrane requires a dedicated molecular machine. A glimpse of this apparatus in action shows that it has two channels, and hints at how these pores might be regulated.

Arnold J. M. Driessen

doi:10.1038/438299a

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Brief Communications

Environmental policy: Regional commitment to reducing emissions p301

Local policy in the United States goes some way towards countering anthropogenic climate change.

Brendan Fisher and Robert Costanza

doi:10.1038/438301a

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Ant navigation: Priming of visual route memories p302

Robert A. Harris, Natalie Hempel de Ibarra, Paul Graham and Thomas S. Collett

doi:10.1038/438302a

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Brief Communications Arising

Origin of flight: Could 'four-winged' dinosaurs fly? pE3

Kevin Padian and Kenneth P. Dial

doi:10.1038/nature04354

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Origin of flight: Could 'four-winged' dinosaurs fly? (Reply) pE3

Xing Xu, Zhonghe Zhou, Xiaolin Wang, Xuewen Kuang, Fucheng Zhang and Xiangke Du

doi:10.1038/nature04355

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Origin of flight: Could 'four-winged' dinosaurs fly? (Reply) pE4

Zhonghe Zhou and Fucheng Zhang

doi:10.1038/nature04355

First paragraph | Full Text | PDF (87K)

Reviews

Potential impacts of a warming climate on water availability in snow-dominated regions p303

T. P. Barnett, J. C. Adam and D. P. Lettenmaier

doi:10.1038/nature04141

Abstract | Full Text | PDF (309K)

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Impact of regional climate change on human health p310

Jonathan A. Patz, Diarmid Campbell-Lendrum, Tracey Holloway and Jonathan A. Foley

doi:10.1038/nature04188

Abstract | Full Text | PDF (664K)

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Articles

Structure of the E. coli protein-conducting channel bound to a translating ribosome p318

Kakoli Mitra, Christiane Schaffitzel, Tanvir Shaikh, Florence Tama, Simon Jenni, Charles L. Brooks, III, Nenad Ban and Joachim Frank

doi:10.1038/nature04133

Abstract | Full Text | PDF (721K) | Supplementary information

See also: Editor's summary | News and Views by Driessen

A light-sensing knot revealed by the structure of the chromophore-binding domain of phytochrome p325

Jeremiah R. Wagner, Joseph S. Brunzelle, Katrina T. Forest and Richard D. Vierstra

doi:10.1038/nature04118

Abstract | Full Text | PDF (569K) | Supplementary information

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Letters

The formation of stars by gravitational collapse rather than competitive accretion p332

Mark R. Krumholz, Christopher F. McKee and Richard I. Klein

doi:10.1038/nature04280

First paragraph | Full Text | PDF (111K) | Supplementary information

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Nanofabricated media with negative permeability at visible frequencies p335

A. N. Grigorenko, A. K. Geim, H. F. Gleeson, Y. Zhang, A. A. Firsov, I. Y. Khrushchev and J. Petrovic

doi:10.1038/nature04242

First paragraph | Full Text | PDF (365K) | Supplementary information

See also: Editor's summary | News and Views by Sambles

Spin-torque diode effect in magnetic tunnel junctions p339

A. A. Tulapurkar, Y. Suzuki, A. Fukushima, H. Kubota, H. Maehara, K. Tsunekawa, D. D. Djayaprawira, N. Watanabe and S. Yuasa

doi:10.1038/nature04207

First paragraph | Full Text | PDF (468K) | Supplementary information

Chaos-based communications at high bit rates using commercial fibre-optic links p343

Apostolos Argyris, Dimitris Syvridis, Laurent Larger, Valerio Annovazzi-Lodi, Pere Colet, Ingo Fischer, Jordi García-Ojalvo, Claudio R. Mirasso, Luis Pesquera and K. Alan Shore

doi:10.1038/nature04275

First paragraph | Full Text | PDF (1,112K)

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Global pattern of trends in streamflow and water availability in a changing climate p347

P. C. D. Milly, K. A. Dunne and A. V. Vecchia

doi:10.1038/nature04312

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Palaeoanatomy and biological affinities of a Cambrian deuterostome (Stylophora) p351

Sébastien Clausen and Andrew B. Smith

doi:10.1038/nature04109

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Superspreading and the effect of individual variation on disease emergence p355

J. O. Lloyd-Smith, S. J. Schreiber, P. E. Kopp and W. M. Getz

doi:10.1038/nature04153

First paragraph | Full Text | PDF (375K) | Supplementary information

See also: Editor's summary | News and Views by Galvani & May

Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube p360

Yuko Muroyama, Yuko Fujiwara, Stuart H. Orkin and David H. Rowitch

doi:10.1038/nature04139

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Control of B-cell responses by Toll-like receptors p364

Chandrashekhar Pasare and Ruslan Medzhitov

doi:10.1038/nature04267

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Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice p369

Ikuhiro Okamoto, Danielle Arnaud, Patricia Le Baccon, Arie P. Otte, Christine M. Disteche, Philip Avner and Edith Heard

doi:10.1038/nature04155

First paragraph | Full Text | PDF (449K) | Supplementary information

See also: News and Views by Reik & Ferguson-Smith

A histone H3 methyltransferase controls epigenetic events required for meiotic prophase p374

Katsuhiko Hayashi, Kayo Yoshida and Yasuhisa Matsui

doi:10.1038/nature04112

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Chromatin remodelling at a DNA double-strand break site in Saccharomyces cerevisiae p379

Toyoko Tsukuda, Alastair B. Fleming, Jac A. Nickoloff and Mary Ann Osley

doi:10.1038/nature04148

First paragraph | Full Text | PDF (367K) | Supplementary information

Force production by disassembling microtubules p384

Ekaterina L. Grishchuk, Maxim I. Molodtsov, Fazly I. Ataullakhanov and J. Richard McIntosh

doi:10.1038/nature04132

First paragraph | Full Text | PDF (379K) | Supplementary information

Naturejobs

Where East meets West p389

The East is offering ways to unseat Western dominance in graduate enrolment and employment.

Paul Smaglik

doi:10.1038/nj7066-389a

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Balancing act p390

Mounting responsibilities can swamp the newly independent scientist. Kendall Powell asks if it's possible to manage your time without losing your creativity.

Kendall Powell

doi:10.1038/nj7066-390a

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Melissa Hines, director, Cornell Center for Materials Research, Ithaca, New York p392

Chemist emphasizes need for public communication.

Virginia Gewin

doi:10.1038/nj7066-392a

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Recruiters & Academia p392

Workshop teaches scientists how to be a professor.

Charlene Sorensen

doi:10.1038/nj7066-392b

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Graduate Journal: Learning from teaching p392

Graduate student gets teaching lessons in the ballroom.

Karolina Tkaczuk

doi:10.1038/nj7066-392c

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Futures

Perchance to dream p394

Out of sight, out of mind.

Robert A. Metzger

doi:10.1038/438394a

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