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Nature 438, 297-298 (17 November 2005) | doi:10.1038/438297a; Published online 16 November 2005
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Developmental biology: The X-inactivation yo-yo
Wolf Reik1 & Anne C. Ferguson-Smith2
Abstract
In female mammals, one of two X chromosomes has to be shut down during early development. To what extent does this 'imprinted X-chromosome inactivation' involve the history of the chromosome?
In most mammals, males have the male sex-determining Y chromosome and a single X chromosome, whereas females have two X chromosomes. In females, the resulting imbalance in the 'dosage' of genes on the X chromosomes needs to be compensated so that gene expression from the X chromosome is equivalent in males and females.
- Wolf Reik is in the Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK.
Email: wolf.reik@bbsrc.ac.uk - Anne C. Ferguson-Smith is in the Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK.
Email: afsmith@mole.bio.cam.ac.uk
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