FIGURE 1. Vaginally delivered inhibitors can protect macaques against vaginal challenge with SHIV-162P3.

From the following article:

Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus–cell fusion

Ronald S. Veazey, Per Johan Klasse, Susan M. Schader, Qinxue Hu, Thomas J. Ketas, Min Lu, Preston A. Marx, Jason Dufour, Richard J. Colonno, Robin J. Shattock, Martin S. Springer and John P. Moore

Nature 438, 99-102 (3 November 2005)

doi:10.1038/nature04055

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Each symbol represents a single macaque, grouped by infection status after challenge. Control animals are shown by red triangles and received HMC gel, pH 6.0; 9 out of 9 became infected. Two monkeys received soluble mannan (50 mg ml-1) to try to block attachment to receptors such as DC-SIGN17 (black circles). The 68 animals given CMPD167, BMS-378806 or C52L, alone or in combination, are depicted by blue diamonds. The virus challenge was 30 min after inhibitor delivery, except for animals denoted as 'CMPD167 [5.0 mM] challenge delay 2–12 h' and 'BMS-368806 [5.5 mM] challenge delay 2–6 h'.

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