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Nature 437, 1370-1375 (27 October 2005) | doi:10.1038/nature04108;
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Wnt signalling regulates adult hippocampal neurogenesis
The generation of new neurons from neural stem cells is restricted to two regions of the adult mammalian central nervous system: the subventricular zone of the lateral ventricle, and the subgranular zone of the hippocampal dentate gyrus. In both regions, signals provided by the microenvironment regulate the maintenance, proliferation and neuronal fate commitment of the local stem cell population.
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