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Volume 437 Issue 7063, 27 October 2005

Editorial

  • A growing chasm separates the growing scientific understanding of sleep, and the widespread public assumption that it just doesn't matter.

    Editorial

    Advertisement

  • The Environmental Protection Agency is ducking a frank assessment of New Orleans after Katrina.

    Editorial
  • The National Academies offers guidance to keep the United States internationally competitive.

    Editorial
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Research Highlights

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News

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News in Brief

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News Feature

  • The flailing limbs of someone acting out their dreams in bed may not seem the obvious place to seek a cure for Parkinson's disease. But, as Alison Abbott finds out, this sleep disorder is shedding fresh light on the development of neurodegenerative disorders.

    • Alison Abbott
    News Feature
  • Ignoring the mainstream, physicist Seth Putterman has a knack for bringing long-forgotten mysteries back to the fore. Geoff Brumfiel discovers some of the payoffs, and perils, of being a fiercely independent researcher.

    • Geoff Brumfiel
    News Feature
  • It's a bizarre, toxin-filled microbe that could clean up sewage plants across the globe. Helen Pilcher gets on the trail of the anammox bacterium.

    • Helen Pilcher
    News Feature
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Business

  • Reform of the patent process in the United States is shaping up as a battle of wills between the software and biotechnology industries. The outcome has global consequences, as Emma Marris reports.

    Business
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Correspondence

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Commentary

  • The next large-scale human genome project after HapMap should catalogue inherited variation in the general population that directly affects gene function, argues Richard Gibbs.

    • Richard Gibbs
    Commentary
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Books & Arts

  • Did the humble mitochondrion — the powerhouse of the cell — play a key role in the evolution of life?

    • John F. Allen
    Books & Arts
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Essay

  • Glycomics: like proteins and nucleic acids, carbohydrates have essential roles in the cell, but the tools to synthesize and analyse this third class of biopolymer have, until recently, lagged far behind.

    • Peter H. Seeberger
    Essay
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News & Views

  • The first edition of a massive catalogue of human genetic variation is now complete. The long-term task is to translate these data into an understanding of the effects of that variation on human health.

    • David B. Goldstein
    • Gianpiero L. Cavalleri
    News & Views
  • The polymer nylon-6 is much in demand. An innovation in producing the precursor molecule, ε-caprolactam, involves a one-step process that is environmentally benign and may be scaled up for bulk production.

    • Robert Mokaya
    • Martyn Poliakoff
    News & Views
  • The semiconductor material used in computing systems does not emit light. But a silicon-based structure that can modulate light from an independent source might aid the marriage of optical and electronic components.

    • Gareth Parry
    News & Views
  • Helicase enzymes can move along DNA or RNA, unravelling the helices as they go. But simply travelling along a nucleic acid in one direction seems not to be enough for some of these molecular motors.

    • Eckhard Jankowsky
    News & Views
  • Chalcogenide materials form the basis of CD and DVD technologies. But an identity crisis looms in the wider field: what role do atomic reconfiguration, electronic processes and ionic movement play in these materials?

    • A. Lindsay Greer
    • Neil Mathur
    News & Views
  • Many proteins are carried within cells in bubble-like sacs. These are pinched off from membranes inside the cell, and it seems that the Sar1p protein is key in both starting and finishing this budding process.

    • Guillaume Drin
    • Bruno Antonny
    News & Views
  • Electrons were until recently thought to transport their charge and spin equally freely through metals and semiconductors. Now it seems that spin can lag considerably behind charge.

    • Bart van Wees
    News & Views
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Brief Communication

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Introduction

    • John Spiro
    Introduction
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Commentary

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Review Article

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Progress Article

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Review Article

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Article

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Letter

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Prospects

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Careers and Recruitment

  • Fearing that it will be the target of future bioterrorist attacks, the United States has been ploughing huge amounts of money into biodefence. The result is a reinvigorated market for microbiologists. Corie Lok reports.

    • Corie Lok
    Careers and Recruitment
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Movers

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Career View

  • ACS finds success with an informal job-hunt forum.

    • Charles Casey
    • Jerry Bell
    Career View
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Graduate Journal

  • New PhD discovers first job brings fresh anxieties

    • Jason Underwood
    Graduate Journal
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Futures

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Authors

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Brief Communications Arising

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Insight

  • It is often true in biology that things are more complex than they first seem, and this is especially accurate for sleep: what is sleep, what are its mechanisms and what is it for? The discovery of Rapid Eye Movement (REM) sleep - an excited state characterised by intense brain activity and vivid dreaming - tells us sleep is not just for rest. With so many unanswered questions, sleep research is an exciting field to follow. In this Insight, Naturehighlights a diverse Collection of articles ranging from how sleep affects our understanding of consciousness to the consolidation of our memories. Supported by the National Institutes of Health. As always,Naturecarries sole responsibility for all editorial content.

    Insight
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