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Nature 437, 1245 (27 October 2005) | doi:10.1038/4371245a; Published online 26 October 2005
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Organic Chemistry
- Praj Matrix - Praj Industries Ltd
- Pune, Maharashtra Pune-411021 India
Senior Researcher in theoretical chemistry / physics
- Italian Institute of Technology
- Lecce, Italy
Biophysics: Helicase snaps back
Eckhard Jankowsky1
Abstract
Helicase enzymes can move along DNA or RNA, unravelling the helices as they go. But simply travelling along a nucleic acid in one direction seems not to be enough for some of these molecular motors.
Proteins of the helicase family are essential for almost all biological processes involving nucleic acids such as DNA, from the replication of the genome to the production of proteins1, 2. Although these enzymes are mainly known for their ability to unwind DNA or RNA helices, it has become increasingly clear that they can have many other activities.
- Eckhard Jankowsky is in the Department of Biochemistry and at the Center for RNA Molecular Biology, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Email: exj13@case.edu
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