Supplementary information
From the following article:
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution
Elodie Ghedin, Naomi A. Sengamalay, Martin Shumway, Jennifer Zaborsky, Tamara Feldblyum, Vik Subbu, David J. Spiro, Jeff Sitz, Hean Koo, Pavel Bolotov, Dmitry Dernovoy, Tatiana Tatusova, Yiming Bao, Kirsten St George, Jill Taylor, David J. Lipman, Claire M. Fraser, Jeffery K. Taubenberger & Steven L. Salzberg
Nature 437, 1162-1166(20 October 2005)
doi:10.1038/nature04239
Supplementary Methods
This file contains additional details of how the influenza genomes were assembled, manually edited, and annotated.
Supplementary Notes S1
This file contains the genome sequences for all 209 samples that are described in this study. Each segment of each isolate is listed as a separate FASTA entry. These files contain reference to the GenBank accession.version number, the species code, the segment number, and the segment name for every segment of each sample.
Supplementary Notes S2
This file contains the translations of the alternatively translated gene from the PB1 segment, known as PB1–2. The "*" character in some of these sequences indicates an in-frame stop codon for those segments whose translation is shorter than 90aa.
Supplementary Notes S3
This file is a catalogue of all H3N2 primers used in the study. Not all were used on all samples.
Supplementary Figure S1a
This file is a more detailed version of Figure 1 in the main text, which shows for each influenza segment all mutations across all 207 H3N2 samples in this study. To facilitate further analysis, this figure is also provided as a comma-separated text file.
Supplementary Figure S1b
A comma-separated version of the data shown in Supplementary Figure S1a.
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