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Nature 437, 1153-1157 (20 October 2005) | doi:10.1038/nature04240;
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PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Dermapathologist
- Indiana University School of Medicine
- Indiana, USA
Natural selection on protein-coding genes in the human genome
Comparisons of DNA polymorphism within species to divergence between species enables the discovery of molecular adaptation in evolutionarily constrained genes as well as the differentiation of weak from strong purifying selection. The extent to which weak negative and positive darwinian selection have driven the molecular evolution of different species varies greatly, with some species, such as Drosophila melanogaster, showing strong evidence of pervasive positive selection, and others, such as the selfing weed Arabidopsis thaliana, showing an excess of deleterious variation within local populations.
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