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Nature 437, 1106 (20 October 2005) | doi:10.1038/4371106a; Published online 19 October 2005

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Evolutionary biology: Fruitfly genome is not junk

Alexey S. Kondrashov1

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A comparison of two fruitfly genomes shows that much of their non-coding DNA is controlled by either negative or positive selection, dealing a double blow to the neutral theory of molecular evolution.

Once upon a time, the world seemed simple when viewed through the eyes of evolutionary biologists. All genomes were tightly controlled by various forms of natural selection.

  1. Alexey S. Kondrashov is at the National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA.
    Email: kondrashov@ncbi.nlm.nih.gov

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