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News and Views
Nature 437, 1103 (20 October 2005) | doi:10.1038/4371103a; Published online 19 October 2005
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Research Assistant Professor, Post-Doctoral Fellow, Statistical Genetic Analyst, and Scientific Programmer Positions in Statistical Human Genetics
- University of Michigan
- Ann Arbor, Michigan, USA
Laboratory Technician (Pharmaceutics)
- Alliance Institute of Advanced Pharmacy and Health Sciences
- Hyderabad 500038 India
Cell biology: A BID for the pathway
Michael B. Kastan1
Abstract
Cells have many ways of coping with damage to their DNA, but how are these all coordinated? It seems that BID — a regulator of programmed cell death — stands at the crossroads of several damage-response pathways.
Exposure to DNA-damaging agents can cause mutations, developmental abnormalities or cancer, and cells have developed numerous ways to minimize these effects. Such mechanisms include cell-cycle checkpoints to prohibit damaged cells from dividing while the cell deals with the damage; processes to repair the DNA; and programmed cell death (apoptosis).
- Michael B. Kastan is in the Department of Hematology–Oncology, St Jude Children's Research Hospital, Room D-5048, 332 North Lauderdale Street, Memphis, Tennessee 38105, USA.
Email: Michael.Kastan@stjude.org
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