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FIGURE 1. Sites with genetic changes across the ten main proteins in 207 influenza A viruses.

From the following article:

Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution

Elodie Ghedin, Naomi A. Sengamalay, Martin Shumway, Jennifer Zaborsky, Tamara Feldblyum, Vik Subbu, David J. Spiro, Jeff Sitz, Hean Koo, Pavel Bolotov, Dmitry Dernovoy, Tatiana Tatusova, Yiming Bao, Kirsten St George, Jill Taylor, David J. Lipman, Claire M. Fraser, Jeffery K. Taubenberger and Steven L. Salzberg

Nature 437, 1162-1166 (20 October 2005)

doi: 10.1038/nature04239


Each row represents a single amino acid position in one protein. Amino acids (single-letter abbreviations are used) are colour-coded as shown in the key, so that mutations can be seen as changes in colour when scanning from left to right along a row. For simplicity, only amino acids that showed changes in at least three isolates are shown. Each column represents a single isolate, and columns are only a few pixels wide in order to display all 207 H3N2 isolates in this figure. Isolates are ordered along the columns chronologically according to the date of collection; boundaries between influenza seasons are indicated by gaps between columns. A more detailed version of this figure, showing positions that experienced any amino acid change and showing identifiers for the isolates in each column, is available as Supplementary Fig. 1.

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