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FIGURE 3. Interaction network of disease-associated CCSB-HI1 proteins.

From the following article:

Towards a proteome-scale map of the human protein–protein interaction network

Jean-François Rual, Kavitha Venkatesan, Tong Hao, Tomoko Hirozane-Kishikawa, Amélie Dricot, Ning Li, Gabriel F. Berriz, Francis D. Gibbons, Matija Dreze, Nono Ayivi-Guedehoussou, Niels Klitgord, Christophe Simon, Mike Boxem, Stuart Milstein, Jennifer Rosenberg, Debra S. Goldberg, Lan V. Zhang, Sharyl L. Wong, Giovanni Franklin, Siming Li, Joanna S. Albala, Janghoo Lim, Carlene Fraughton, Estelle Llamosas, Sebiha Cevik, Camille Bex, Philippe Lamesch, Robert S. Sikorski, Jean Vandenhaute, Huda Y. Zoghbi, Alex Smolyar, Stephanie Bosak, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael E. Cusick, David E. Hill, Frederick P. Roth and Marc Vidal

Nature 437, 1173-1178 (20 October 2005)

doi: 10.1038/nature04209


The network has 121 OMIM disease-associated proteins (green nodes) and 424 CCSB-HI1 interactions involving them (red edges), along with known LC interactions (solid blue edges represent binary LCI interactions and dashed blue edges represent non-binary interactions). Proteins without an OMIM disease association are depicted as yellow nodes, and blue edges with increasing thickness indicate LCI-non-core, LCI-core and LCI-hypercore interactions, respectively. We note that 94 out of the 424 CCSB-HI1 interactions involve the Ewing sarcoma related protein (EWSR1; also known as EWS).

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