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FIGURE 2. Overlap of CCSB-HI1 with existing literature-curated (LC) data.

From the following article:

Towards a proteome-scale map of the human protein–protein interaction network

Jean-François Rual, Kavitha Venkatesan, Tong Hao, Tomoko Hirozane-Kishikawa, Amélie Dricot, Ning Li, Gabriel F. Berriz, Francis D. Gibbons, Matija Dreze, Nono Ayivi-Guedehoussou, Niels Klitgord, Christophe Simon, Mike Boxem, Stuart Milstein, Jennifer Rosenberg, Debra S. Goldberg, Lan V. Zhang, Sharyl L. Wong, Giovanni Franklin, Siming Li, Joanna S. Albala, Janghoo Lim, Carlene Fraughton, Estelle Llamosas, Sebiha Cevik, Camille Bex, Philippe Lamesch, Robert S. Sikorski, Jean Vandenhaute, Huda Y. Zoghbi, Alex Smolyar, Stephanie Bosak, Reynaldo Sequerra, Lynn Doucette-Stamm, Michael E. Cusick, David E. Hill, Frederick P. Roth and Marc Vidal

Nature 437, 1173-1178 (20 October 2005)

doi: 10.1038/nature04209


a, Overlap between CCSB-HI1 and LC interactions in Space-I (LCI). The top, middle and bottom panels represent the overlap between CCSB-HI1 and LCI, LCI-core and LCI-hypercore, respectively. b, Network graph of the union of all CCSB-HI1 and LCI interactions. Proteins are shown as yellow nodes and CCSB-HI1 and LCI interactions are shown as red and blue edges, respectively. Blue edges with increasing thickness indicate LCI-non-core, LCI-core and LCI-hypercore, respectively. The apparent banding pattern of the yellow nodes is an artefact of the graph layout algorithm (Supplementary Data). Importantly, the layout algorithm was not informed by type of supporting evidence and therefore does not explain the evident separation of blue and red edges. c, Bias in 2-hop network neighbourhood for either CCSB-HI1 or LCI interactions. The frequency of nodes with a given proportion of CCSB-HI1 interactions in their 2-hop neighbourhood is depicted for the interactome network graph in b (solid curve) and for a network in which the types of supporting evidence (CCSB-HI1 or LCI) are randomly permuted among edges (dashed curve). The solid curve indicates that most of the proteins in the network of b have either only CCSB-HI1 or only LCI interactions in their 2-hop neighbourhood. In contrast, neighbourhoods are well mixed when evidence labels are randomly permuted among edges.

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