How the search for parasite vaccines led to the production of a super rubber.
doi: 10.1038/7061xiiia
Table of contents
Volume 437 Number 7061 ppxiii-1064
In this issue (13 October 2005)
Also this week
Top of page
Authors
Making the paper: Christopher Elvin pxiii
Abstractions pxiii
doi: 10.1038/7061xiiib
Quantified: Denmark pxiii
doi: 10.1038/7061xiiic
Top of page
Editorials
Peace and honour p927
The 2005 Nobel Peace Prize is a timely reminder of the good work done by the International Atomic Energy Agency and its director, Mohamed ElBaradei.
doi: 10.1038/437927a
From rhetoric to reality p927
President Bush's acknowledgement of the threat ofpandemic flu is welcome, if belated.
doi: 10.1038/437927b
Advise the president p928
The merger of two White House advisory panelssends out the wrong message.
doi: 10.1038/437928a
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News
US progressives fight for a voice in bioethics p932
Left-leaning think-tank aims to influence political decisions.
Erika Check
doi: 10.1038/437932a
Nuclear group nabs peace prize p932
Sidelines p933
doi: 10.1038/437933a
More evidence for hobbit unearthed as diggers are refused access to cave p934
Excavations shed light on lifestyle of Homo floresiensis.
Rex Dalton
doi: 10.1038/437934a
Indonesia struggles to control bird flu outbreak p937
As officials in Washington discuss how to tackle outbreaks of bird flu more effectively (see From rhetoric to reality ), an outbreak in humans continues in Asia. Declan Butler assesses the situation in Indonesia, and finds out how likely it is that the virus might evolve into a pandemic strain.
Declan Butler
doi: 10.1038/437937a
Chemical exchange captures Nobel p938
Prize goes to trio who transformed organic synthesis.
Philip Ball
doi: 10.1038/437938a
Ig Nobels hail world's longest-running experiment p938
Distinguished scientists gather in Boston for silliness awards.
Steve Nadis
doi: 10.1038/437938b
News in brief p940
doi: 10.1038/437940a
Correction p940
doi: 10.1038/437940b
Top of page
News Features
Drug discovery: Playing dirty p942
Forget drugs carefully designed to hit one particular molecule — a better way of treating complex diseases such as cancer may be to aim for several targets at once, says Simon Frantz.
Simon Frantz
doi: 10.1038/437942a
Conservation in Brazil: The forgotten ecosystem p944
Everyone knows about the Amazon rainforest, but Brazil's tropical savannah is arguably under greater threat. Emma Marris visits a testing ground for future conservation strategies.
Emma Marris
doi: 10.1038/437944a
Neuroscience: The maestro of minds p946
With a mathematician's logic and the perfectionism of a concert pianist, Nikos Logothetis is making waves in cognitive neuroscience — and putting the German town of Tübingen on the scientific map. Alison Abbott pays him a visit.
Alison Abbott
doi: 10.1038/437946a
Top of page
Business
The technology trap p948
America's widely-admired system for transferring ideas from the lab to the marketplace is showing signs of distress. Virginia Gewin reports.
Virginia Gewin
doi: 10.1038/437948a
In brief p949
doi: 10.1038/437949a
Market watch p949
doi: 10.1038/437949b
Top of page
Correspondence
Re-wilding: a bold plan that needs native megafauna p951
Evolution was fine, just not in the case of humans p951
NIH moved quickly to help researchers after Katrina p951
Indian players in some of IT and biotech's top teams p951
System to rank scientists was pedalled by Jeffreys p951
Top of page
Books and Arts
Before the storm p953
Katrina grabbed the headlines recently, but hurricanes have been a focus of attention for centuries.
doi: 10.1038/437953a
Fetal affliction p954
doi: 10.1038/437954a
Nuclear reactions p955
doi: 10.1038/437955a
Exhibition: Collectors' items p955
doi: 10.1038/437955b
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News and Views
古人類学：フロレス島でのさらなる化石発見
Palaeoanthropology: Further fossil finds from Flores p957
New fossil discoveries on Flores, Indonesia, bolster the evidence that Homo floresiensis was a dwarfed human species that lived at the end of the last ice age. But the species' evolutionary origins remain obscure.
Daniel E. Lieberman
doi: 10.1038/437957a
惑星科学：ディープインパクト計画のインパクト
Planetary science: The impact of Deep Impact p958
A good look at the Deep Impact cometary encounter was taken by the Rosetta mission, itself on the way to a rendezvous with a comet in 2014. So what is a comet — icy dustball or dusty iceball?
Paul D. Feldman
doi: 10.1038/437958a
生態学：安定性の根っこ
Ecology: Roots of stability p959
The 'insurance hypothesis' holds that ecosystem diversity is a good thing because diversity confers overall stability in the face of stressful conditions. Experiments on grassland support that view.
Peter D. Moore
doi: 10.1038/437959a
材料科学：ぐーんと伸びる新材料
Materials science: At a stretch p961
デバイス物理学：邪魔にならないノイズ
Device physics: No-nuisance noise p962
'Silence is golden' is a maxim of limited applicability where stochastic resonance holds sway. The effect uses noise to boost signal output in certain systems — and has just been seen in oscillators on a very small scale.
Adi R. Bulsara
doi: 10.1038/437962a
発生生物学：細胞周期の束縛を外すと
Developmental biology: Cell cycle unleashed p963
How does fertilization cause animal eggs to begin embryonic development? Following entry of the sperm, the ingeniously regulated degradation of a protein seems to kick-start the stalled cell cycle.
Takeo Kishimoto
doi: 10.1038/437963a
50 & 100 years ago p963
doi: 10.1038/437963ba
植物生理学：木にとって大事な問題
Plant physiology: A big issue for trees p965
The age of a tree and its size tend to increase together. Disentangling the effects of these two factors on tree vitality is no easy task, but further evidence adds to the view that it is size that matters.
Josep Peñuelas
doi: 10.1038/437965a
Top of page
Brief Communications
Culinary archaeology: Millet noodles in Late Neolithic China p967
A remarkable find allows the reconstruction of the earliest recorded preparation of noodles.
Houyuan Lu, Xiaoyan Yang, Maolin Ye, Kam-Biu Liu, Zhengkai Xia, Xiaoyan Ren, Linhai Cai, Naiqin Wuand Tung-Sheng Liu
doi: 10.1038/437967a
First paragraph | Full Text| PDF (444K) | Supplementary information
Microwave devices: Carbon nanotubes as cold cathodes p968
Kenneth B. K. Teo, Eric Minoux, Ludovic Hudanski, Franck Peauger, Jean-Philippe Schnell, Laurent Gangloff, Pierre Legagneux, Dominique Dieumegard, Gehan A. J. Amaratungaand William I. Milne
doi: 10.1038/437968a
First paragraph | Full Text| PDF (194K) | Supplementary information
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Articles
地球：2004年パークフィールド地震から得られた結果が地震予知と災害評価にもたらす影響
Implications for prediction and hazard assessment from the 2004 Parkfield earthquake p969
W. H. Bakun, B. Aagaard, B. Dost, W. L. Ellsworth, J. L. Hardebeck, R. A. Harris, C. Ji, M. J. S. Johnston, J. Langbein, J. J. Lienkaemper, A. J. Michael, J. R. Murray, R. M. Nadeau, P. A. Reasenberg, M. S. Reichle, E. A. Roeloffs, A. Shakal, R. W. Simpsonand F. Waldhauser
doi: 10.1038/nature04067
微生物：plectasinは治療効果を期待できる腐生菌由来ペプチド性抗生物質である
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus p975
Per H. Mygind, Rikke L. Fischer, Kirk M. Schnorr, Mogens T. Hansen, Carsten P. Sönksen, Svend Ludvigsen, Dorotea Raventós, Steen Buskov, Bjarke Christensen, Leonardo De Maria, Olivier Taboureau, Debbie Yaver, Signe G. Elvig-Jørgensen, Marianne V. Sørensen, Bjørn E. Christensen, Søren Kjærulff, Niels Frimodt-Moller, Robert I. Lehrer, Michael Zasloffand Hans-Henrik Kristensen
doi: 10.1038/nature04051
生化学：多数の調節因子のレベルを制御する一酸化窒素センサーとしてのN末端則経路
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators p981
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashiand Alexander Varshavsky
doi: 10.1038/nature04027
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Letters
宇宙：彗星9P/Tempel 1の核におけるダスト/氷の大きな比率
A large dust/ice ratio in the nucleus of comet 9P/Tempel 1 p987
Michael Küppers, Ivano Bertini, Sonia Fornasier, Pedro J. Gutierrez, Stubbe F. Hviid, Laurent Jorda, Horst Uwe Keller, Jörg Knollenberg, Detlef Koschny, Rainer Kramm, Luisa-Maria Lara, Holger Sierks, Nicolas Thomas, Cesare Barbieri, Philippe Lamy, Hans Rickman, Rafael Rodrigoand The OSIRIS team
doi: 10.1038/nature04236
宇宙：火星のアマゾン代の北極に位置する物質の地質学および日射により駆動される気候史
Geology and insolation-driven climatic history of Amazonian north polar materials on Mars p991
ナノテクノロジー：確率共鳴による双安定ナノメカニカル振動子のコヒーレントなシグナル増幅
Coherent signal amplification in bistable nanomechanical oscillators by stochastic resonance p995
生化学：架橋組み換えプロレシリンの合成と性質
Synthesis and properties of crosslinked recombinant pro-resilin p999
Christopher M. Elvin, Andrew G. Carr, Mickey G. Huson, Jane M. Maxwell, Roger D. Pearson, Tony Vuocolo, Nancy E. Liyou, Darren C. C. Wong, David J. Merrittand Nicholas E. Dixon
doi: 10.1038/nature04085
気候：過去2万年間における中央アフリカの水文学的特徴への気候による制御
Climatic controls on central African hydrology during the past 20,000 years p1003
Enno Schefu
, Stefan Schoutenand Ralph R. Schneider
doi: 10.1038/nature03945
進化：南米で最古のドロマエオサウルス科獣脚類
The earliest dromaeosaurid theropod from South America p1007
Peter J. Makovicky, Sebastián Apesteguíaand Federico L. Agnolín
doi: 10.1038/nature03996
進化：更新世後期にインドネシアのフロレス島に小柄なヒト族がいたことを示すさらなる証拠
Further evidence for small-bodied hominins from the Late Pleistocene of Flores, Indonesia p1012
M. J. Morwood, P. Brown, Jatmiko, T. Sutikna, E. Wahyu Saptomo, K. E. Westaway, Rokus Awe Due, R. G. Roberts, T. Maeda, S. Wasistoand T. Djubiantono
doi: 10.1038/nature04022
発生：脊椎動物のSmoothenedは一次繊毛において機能する
Vertebrate Smoothened functions at the primary cilium p1018
Kevin C. Corbit, Pia Aanstad, Veena Singla, Andrew R. Norman, Didier Y. R. Stainierand Jeremy F. Reiter
doi: 10.1038/nature04117
植物：シロイヌナズナではSERRATEが茎頂分裂組織の機能と葉の軸性パターン形成を協調させている
SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis p1022
Stephen P. Grigg, Claudia Canales, Angela Hayand Miltos Tsiantis
doi: 10.1038/nature04052
神経：In vivoでの繰り返しコカイン暴露は中脳ドーパミン性ニューロンでのLTP誘発を促進する
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons p1027
Qing-song Liu, Lu Puand Mu-ming Poo
doi: 10.1038/nature04050
細胞：ヒトの全身性炎症のネットワークに基づく解析
A network-based analysis of systemic inflammation in humans p1032
Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkins, Stephen F. Lowryand Inflamm and Host Response to Injury Large Scale Collab. Res. Program
doi: 10.1038/nature03985
細胞：ヒトの細胞株では染色体不分離によって異数体細胞ではなく四倍体細胞が生じる
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines p1038
Qinghua Shiand Randall W. King
doi: 10.1038/nature03958
細胞：細胞質分裂の失敗による四倍体の生成がp53ヌル細胞で腫瘍形成を促進する
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells p1043
Takeshi Fujiwara, Madhavi Bandi, Masayuki Nitta, Elena V. Ivanova, Roderick T. Bronsonand David Pellman
doi: 10.1038/nature04217
細胞：カルシウムはAPC/C阻害因子XErp1を分解標的にさせることで、減数第二分裂から次の段階への進行を誘導する
Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation p1048
Nadine R. Rauh, Andreas Schmidt, Jenny Bormann, Erich A. Niggand Thomas U. Mayer
doi: 10.1038/nature04093
生化学：タンパク質の変性状態とフォールディング中間体の溶液構造
Solution structure of a protein denatured state and folding intermediate p1053
T. L. Religa, J. S. Markson, U. Mayor, S. M. V. Freundand A. R. Fersht
doi: 10.1038/nature04054
Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription p1057
Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannonand Robin C. Allshire
doi: 10.1038/nature04181
Retraction: Negative lattice expansion from the superconductivity–antiferromagnetism crossover in ruthenium copper oxides p1057
Retraction: Formation of zirconium metallic glass p1057
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Region
Spotlight
Naturejobs
ProspectThe exception to the rule p1059
Just how level should the playing field be for postdoc pay scales?
Paul Smaglik
doi:10.1038/nj7060-1059a
Region
Primed for a biotech boom p1060
Biologists in Osaka think that their city's 'un-Japanese' culture makes it the ideal part of the country to become a hub for biotechnology. David Cyranoski investigates.
David Cyranoski
doi:10.1038/nj7061-1060a
Spotlight
Spotlight on Osaka
doi:10.1038/nj0093
