Table of contents
Volume 437 Number 7061 pp927-1064
Editorials
Peace and honour p927
The 2005 Nobel Peace Prize is a timely reminder of the good work done by the International Atomic Energy Agency and its director, Mohamed ElBaradei.
doi: 10.1038/437927a
From rhetoric to reality p927
President Bush's acknowledgement of the threat of pandemic flu is welcome, if belated.
doi: 10.1038/437927b
Advise the president p928
The merger of two White House advisory panels sends out the wrong message.
doi: 10.1038/437928a
News
US progressives fight for a voice in bioethics p932
Left-leaning think-tank aims to influence political decisions.
Erika Check
doi: 10.1038/437932a
Nuclear group nabs peace prize p932
Jim Giles
doi: 10.1038/437932b
Sidelines p933
doi: 10.1038/437933a
More evidence for hobbit unearthed as diggers are refused access to cave p934
Excavations shed light on lifestyle of Homo floresiensis.
Rex Dalton
doi: 10.1038/437934a
See also: Editor's summary
Indonesia struggles to control bird flu outbreak p937
As officials in Washington discuss how to tackle outbreaks of bird flu more effectively (see From rhetoric to reality ), an outbreak in humans continues in Asia. Declan Butler assesses the situation in Indonesia, and finds out how likely it is that the virus might evolve into a pandemic strain.
Declan Butler
doi: 10.1038/437937a
Chemical exchange captures Nobel p938
Prize goes to trio who transformed organic synthesis.
Philip Ball
doi: 10.1038/437938a
Ig Nobels hail world's longest-running experiment p938
Distinguished scientists gather in Boston for silliness awards.
Steve Nadis
doi: 10.1038/437938b
News in brief p940
doi: 10.1038/437940a
Correction p940
doi: 10.1038/437940b
News Features
Drug discovery: Playing dirty p942
Forget drugs carefully designed to hit one particular molecule — a better way of treating complex diseases such as cancer may be to aim for several targets at once, says Simon Frantz.
doi: 10.1038/437942a
Conservation in Brazil: The forgotten ecosystem p944
Everyone knows about the Amazon rainforest, but Brazil's tropical savannah is arguably under greater threat. Emma Marris visits a testing ground for future conservation strategies.
doi: 10.1038/437944a
See also: Editor's summary
Neuroscience: The maestro of minds p946
With a mathematician's logic and the perfectionism of a concert pianist, Nikos Logothetis is making waves in cognitive neuroscience — and putting the German town of Tübingen on the scientific map. Alison Abbott pays him a visit.
doi: 10.1038/437946a
See also: Editor's summary
Business
The technology trap p948
America's widely-admired system for transferring ideas from the lab to the marketplace is showing signs of distress. Virginia Gewin reports.
Virginia Gewin
doi: 10.1038/437948a
See also: Editor's summary
In brief p949
doi: 10.1038/437949a
Market watch p949
doi: 10.1038/437949b
Correspondence
Re-wilding: a bold plan that needs native megafauna p951
Martin A. Schlaepfer
doi: 10.1038/437951a
Evolution was fine, just not in the case of humans p951
U Kutschera
doi: 10.1038/437951b
NIH moved quickly to help researchers after Katrina p951
Elias Zerhouni
doi: 10.1038/437951c
Indian players in some of IT and biotech's top teams p951
Mukund Mehrotra
doi: 10.1038/437951d
System to rank scientists was pedalled by Jeffreys p951
A. W. F. Edwards
doi: 10.1038/437951e
Books and Arts
Before the storm p953
Katrina grabbed the headlines recently, but hurricanes have been a focus of attention for centuries.
Howard B. Bluestein reviews Divine Wind: The History and Science of Hurricanes by Kerry Emanuel
doi: 10.1038/437953a
Fetal affliction p954
Michael Sargent reviews The Fetal Matrix: Evolution, Development and Disease by Peter Gluckman and Mark Hanson
doi: 10.1038/437954a
Nuclear reactions p955
Brenda Howard reviews Wormwood Forest: A Natural History of Chernobyl by Mary Mycio
doi: 10.1038/437955a
Exhibition: Collectors' items p955
doi: 10.1038/437955b
News and Views
Palaeoanthropology: Further fossil finds from Flores p957
New fossil discoveries on Flores, Indonesia, bolster the evidence that Homo floresiensis was a dwarfed human species that lived at the end of the last ice age. But the species' evolutionary origins remain obscure.
Daniel E. Lieberman
doi: 10.1038/437957a
See also: Editor's summary
Planetary science: The impact of Deep Impact p958
A good look at the Deep Impact cometary encounter was taken by the Rosetta mission, itself on the way to a rendezvous with a comet in 2014. So what is a comet — icy dustball or dusty iceball?
Paul D. Feldman
doi: 10.1038/437958a
See also: Editor's summary
Ecology: Roots of stability p959
The 'insurance hypothesis' holds that ecosystem diversity is a good thing because diversity confers overall stability in the face of stressful conditions. Experiments on grassland support that view.
Peter D. Moore
doi: 10.1038/437959a
Materials science: At a stretch p961
Rosamund Daw
doi: 10.1038/437961a
See also: Editor's summary
Device physics: No-nuisance noise p962
'Silence is golden' is a maxim of limited applicability where stochastic resonance holds sway. The effect uses noise to boost signal output in certain systems — and has just been seen in oscillators on a very small scale.
Adi R. Bulsara
doi: 10.1038/437962a
Developmental biology: Cell cycle unleashed p963
How does fertilization cause animal eggs to begin embryonic development? Following entry of the sperm, the ingeniously regulated degradation of a protein seems to kick-start the stalled cell cycle.
Takeo Kishimoto
doi: 10.1038/437963a
50 & 100 years ago p963
doi: 10.1038/437963ba
Plant physiology: A big issue for trees p965
The age of a tree and its size tend to increase together. Disentangling the effects of these two factors on tree vitality is no easy task, but further evidence adds to the view that it is size that matters.
Josep Peñuelas
doi: 10.1038/437965a
Brief Communications
Culinary archaeology: Millet noodles in Late Neolithic China p967
A remarkable find allows the reconstruction of the earliest recorded preparation of noodles.
Houyuan Lu, Xiaoyan Yang, Maolin Ye, Kam-Biu Liu, Zhengkai Xia, Xiaoyan Ren, Linhai Cai, Naiqin Wu and Tung-Sheng Liu
doi: 10.1038/437967a
First paragraph | Full Text | PDF (444K) | Supplementary information
See also: Editor's summary
Microwave devices: Carbon nanotubes as cold cathodes p968
Kenneth B. K. Teo, Eric Minoux, Ludovic Hudanski, Franck Peauger, Jean-Philippe Schnell, Laurent Gangloff, Pierre Legagneux, Dominique Dieumegard, Gehan A. J. Amaratunga and William I. Milne
doi: 10.1038/437968a
First paragraph | Full Text | PDF (194K) | Supplementary information
Articles
Implications for prediction and hazard assessment from the 2004 Parkfield earthquake p969
W. H. Bakun, B. Aagaard, B. Dost, W. L. Ellsworth, J. L. Hardebeck, R. A. Harris, C. Ji, M. J. S. Johnston, J. Langbein, J. J. Lienkaemper, A. J. Michael, J. R. Murray, R. M. Nadeau, P. A. Reasenberg, M. S. Reichle, E. A. Roeloffs, A. Shakal, R. W. Simpson and F. Waldhauser
doi: 10.1038/nature04067
Abstract | Full Text | PDF (1,289K) | Supplementary information
See also: Editor's summary | Authors
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus p975
Per H. Mygind, Rikke L. Fischer, Kirk M. Schnorr, Mogens T. Hansen, Carsten P. Sönksen, Svend Ludvigsen, Dorotea Raventós, Steen Buskov, Bjarke Christensen, Leonardo De Maria, Olivier Taboureau, Debbie Yaver, Signe G. Elvig-Jørgensen, Marianne V. Sørensen, Bjørn E. Christensen, Søren Kjærulff, Niels Frimodt-Moller, Robert I. Lehrer, Michael Zasloff and Hans-Henrik Kristensen
doi: 10.1038/nature04051
Abstract | Full Text | PDF (394K) | Supplementary information
See also: Editor's summary
The N-end rule pathway as a nitric oxide sensor controlling the levels of multiple regulators p981
Rong-Gui Hu, Jun Sheng, Xin Qi, Zhenming Xu, Terry T. Takahashi and Alexander Varshavsky
doi: 10.1038/nature04027
Abstract | Full Text | PDF (369K) | Supplementary information
See also: Editor's summary
Letters
A large dust/ice ratio in the nucleus of comet 9P/Tempel 1 p987
Michael Küppers, Ivano Bertini, Sonia Fornasier, Pedro J. Gutierrez, Stubbe F. Hviid, Laurent Jorda, Horst Uwe Keller, Jörg Knollenberg, Detlef Koschny, Rainer Kramm, Luisa-Maria Lara, Holger Sierks, Nicolas Thomas, Cesare Barbieri, Philippe Lamy, Hans Rickman, Rafael Rodrigo and The OSIRIS team
doi: 10.1038/nature04236
First paragraph | Full Text | PDF (267K)
See also: Editor's summary
Geology and insolation-driven climatic history of Amazonian north polar materials on Mars p991
Kenneth L. Tanaka
doi: 10.1038/nature04065
First paragraph | Full Text | PDF (389K)
See also: Editor's summary
Coherent signal amplification in bistable nanomechanical oscillators by stochastic resonance p995
Robert L. Badzey and Pritiraj Mohanty
doi: 10.1038/nature04124
First paragraph | Full Text | PDF (555K)
Synthesis and properties of crosslinked recombinant pro-resilin p999
Christopher M. Elvin, Andrew G. Carr, Mickey G. Huson, Jane M. Maxwell, Roger D. Pearson, Tony Vuocolo, Nancy E. Liyou, Darren C. C. Wong, David J. Merritt and Nicholas E. Dixon
doi: 10.1038/nature04085
First paragraph | Full Text | PDF (271K) | Supplementary information
See also: Editor's summary | Authors
Climatic controls on central African hydrology during the past 20,000 years p1003
Enno Schefu
, Stefan Schouten
and Ralph R. Schneider
doi: 10.1038/nature03945
First paragraph | Full Text | PDF (356K)
The earliest dromaeosaurid theropod from South America p1007
Peter J. Makovicky, Sebastián Apesteguía and Federico L. Agnolín
doi: 10.1038/nature03996
First paragraph | Full Text | PDF (551K) | Supplementary information
See also: Editor's summary
Further evidence for small-bodied hominins from the Late Pleistocene of Flores, Indonesia p1012
M. J. Morwood, P. Brown, Jatmiko, T. Sutikna, E. Wahyu Saptomo, K. E. Westaway, Rokus Awe Due, R. G. Roberts, T. Maeda, S. Wasisto and T. Djubiantono
doi: 10.1038/nature04022
First paragraph | Full Text | PDF (539K) | Supplementary information
See also: Editor's summary
Vertebrate Smoothened functions at the primary cilium p1018
Kevin C. Corbit, Pia Aanstad, Veena Singla, Andrew R. Norman, Didier Y. R. Stainier and Jeremy F. Reiter
doi: 10.1038/nature04117
First paragraph | Full Text | PDF (372K) | Supplementary information
See also: Editor's summary
SERRATE coordinates shoot meristem function and leaf axial patterning in Arabidopsis p1022
Stephen P. Grigg, Claudia Canales, Angela Hay and Miltos Tsiantis
doi: 10.1038/nature04052
First paragraph | Full Text | PDF (423K) | Supplementary information
Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons p1027
Qing-song Liu, Lu Pu and Mu-ming Poo
doi: 10.1038/nature04050
First paragraph | Full Text | PDF (766K) | Supplementary information
See also: Editor's summary
A network-based analysis of systemic inflammation in humans p1032
Steve E. Calvano, Wenzhong Xiao, Daniel R. Richards, Ramon M. Felciano, Henry V. Baker, Raymond J. Cho, Richard O. Chen, Bernard H. Brownstein, J. Perren Cobb, S. Kevin Tschoeke, Carol Miller-Graziano, Lyle L. Moldawer, Michael N. Mindrinos, Ronald W. Davis, Ronald G. Tompkins, Stephen F. Lowry and Inflamm and Host Response to Injury Large Scale Collab. Res. Program
doi: 10.1038/nature03985
First paragraph | Full Text | PDF (629K) | Supplementary information
Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines p1038
Qinghua Shi and Randall W. King
doi: 10.1038/nature03958
First paragraph | Full Text | PDF (1,331K) | Supplementary information
See also: Editor's summary
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells p1043
Takeshi Fujiwara, Madhavi Bandi, Masayuki Nitta, Elena V. Ivanova, Roderick T. Bronson and David Pellman
doi: 10.1038/nature04217
First paragraph | Full Text | PDF (475K) | Supplementary information
Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation p1048
Nadine R. Rauh, Andreas Schmidt, Jenny Bormann, Erich A. Nigg and Thomas U. Mayer
doi: 10.1038/nature04093
First paragraph | Full Text | PDF (416K) | Supplementary information
Solution structure of a protein denatured state and folding intermediate p1053
T. L. Religa, J. S. Markson, U. Mayor, S. M. V. Freund and A. R. Fersht
doi: 10.1038/nature04054
First paragraph | Full Text | PDF (767K) | Supplementary information
Retraction: RNA-interference-directed chromatin modification coupled to RNA polymerase II transcription p1057
Vera Schramke, Daniel M. Sheedy, Ahmet M. Denli, Carolina Bonila, Karl Ekwall, Gregory J. Hannon and Robin C. Allshire
doi: 10.1038/nature04181
Retraction: Negative lattice expansion from the superconductivity–antiferromagnetism crossover in ruthenium copper oxides p1057
A. C. Mclaughlin, F. Sher and J. P. Attfield
doi: 10.1038/nature04182
Retraction: Formation of zirconium metallic glass p1057
Jianzhong Zhang and Yusheng Zhao
doi: 10.1038/nature04183
Naturejobs
ProspectThe exception to the rule p1059
Just how level should the playing field be for postdoc pay scales?
Paul Smaglik
doi:10.1038/nj7060-1059a
Region
Primed for a biotech boom p1060
Biologists in Osaka think that their city's 'un-Japanese' culture makes it the ideal part of the country to become a hub for biotechnology. David Cyranoski investigates.
David Cyranoski
doi:10.1038/nj7061-1060a
Spotlight
Spotlight on Osaka
doi:10.1038/nj0093
