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News and Views
Nature 437, 963-965 (13 October 2005) | doi:10.1038/437963a; Published online 12 October 2005
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Director, UQ Centre for Clinical Research
- University of Queensland, Brisbane, Australia
- Brisbane, Queensland, Australia
Director of Bioinformatics
- University of the Witwatersrand, Johannesburg
- Johannesburg, South Africa
Developmental biology: Cell cycle unleashed
Takeo Kishimoto1
Abstract
How does fertilization cause animal eggs to begin embryonic development? Following entry of the sperm, the ingeniously regulated degradation of a protein seems to kick-start the stalled cell cycle.
In animal eggs, the cell-division cycle is held in check part-way through, awaiting sperm entry. A major event after fertilization is therefore the alleviation of this blockage so that cell division can begin in earnest to form the embryo.
- Takeo Kishimoto is in the Laboratory of Cell and Developmental Biology, Graduate School of Bioscience, Tokyo Institute of Technology, Nagatsuta, Midoriku, Yokohama 226-8501, Japan.
Email: tkishimo@bio.titech.ac.jp
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