FIGURE 5. Schematic of interactions of bidentate-bound S-HPP with protein, water and Fe(ii).
From the following article:
Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme
Luke J. Higgins, Feng Yan, Pinghua Liu, Hung-wen Liu and Catherine L. Drennan
Nature 437, 838-844 (1 October 2005)
doi: 10.1038/nature03924
Water shown as a grey sphere. Residues within the substrate hydrophobic cavity are labelled (semicircles) and include Phe 182. Hydrogen-bonding contacts (dotted lines) are shown with distances indicated in Å. For simplicity, the interaction of the Arg 97 guanidinium with the phosphonic acid moiety (
3.4–3.6 Å) is not shown.