Editorials

Bridging the gulf p595

Ecologists and conservationists need to work more closely with economists and policy-makers if they are to make things happen on the ground.

doi: 10.1038/437595a

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A missed opportunity? p595

Japan's prime minister has a valuable chance to reform his nation's tired scientific institutions.

doi: 10.1038/437595b

Full Text | PDF (134K)

Do or die for design p596

A critical court case is addressing the teaching of 'intelligent design' in American schools.

doi: 10.1038/437596a

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Research Highlights

Research highlights p598

doi: 10.1038/437598a

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Corrections p599

doi: 10.1038/437599a

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News

Scientists unite in bid to drive policy p600

US researchers resort to politics to advance their cause.

Rex Dalton

doi: 10.1038/437600a

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Use of NIH funds placed under a spotlight p601

Congressman questions whether grants are being wisely.

Emma Marris

doi: 10.1038/437601a

Full Text | PDF (1,943K)

Pioneering HIV treatment would use interference and gene therapy p601

Researchers lay plans to test ambitious therapy.

Erika Check

doi: 10.1038/437601b

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Snapshot: Judges fall for a leaf's star quality p602

Image captures a plant's anti-insect armoury.

doi: 10.1038/437602a

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Europe tells Russia it faces HIV ruin p602

Government urged to act to prevent disaster.

Quirin Schiermeier

doi: 10.1038/437602b

Full Text | PDF (397K)

Political deadlock leaves scientists frustrated p603

Revision of research rules unlikely in wake of German election.

Quirin Schiermeier

doi: 10.1038/437603a

Full Text | PDF (573K)

Science comes second as NASA makes lunar plans p605

Engineering takes pole position as Moon missions shape up.

Tony Reichhardt

doi: 10.1038/437605a

Full Text | PDF (161K)

Sidelines p605

doi: 10.1038/437605b

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Cancer chief embraces top drugs job p606

Cancer chief takes on additional role at embattled FDA.

Meredith Wadman

doi: 10.1038/437606a

Full Text | PDF (401K)

Into the eye of the storm p607

As Hurricane Rita headed for the US coast, Mark Schrope scored a rare trip into the gathering winds.

doi: 10.1038/437607a

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School board in court over bid to teach intelligent design p607

Parents fight decision to include intelligent creator in science lessons.

Geoff Brumfiel

doi: 10.1038/437607b

Full Text | PDF (130K)

News in brief p608

doi: 10.1038/437608a

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Correction p609

doi: 10.1038/437609a

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News Features

Space telescopes: Mountain at the top p610

With one ageing telescope in space, and another mired in construction troubles on Earth, Matt Mountain has a tough job to do. Jeff Kanipe meets the new custodian of everyone's favourite space telescope.

doi: 10.1038/437610a

Full Text | PDF (516K)

See also: Editor's summary

Marine technology: Back to the bottom p612

Marine scientists are getting ready for their newest tool, a versatile robot submersible that can travel into the oceans' deepest abyss. Robert Cooke visits the Massachusetts lab where the future of deep-sea exploration is taking shape.

doi: 10.1038/437612a

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Conservation: Dollars and sense p614

Approaches to conservation that seek to protect the most endangered species have had only mixed success. Is it time to move away from biodiversity 'hotspots', and stress the economic value of ecosystems? Lucy Odling-Smee investigates.

doi: 10.1038/437614a

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Business

Appetite downer awaits approval p618

A pill that works by putting the hunger induced by cannabis into reverse could jump-start a languishing market for obesity drugs, reports Meredith Wadman.

Meredith Wadman

doi: 10.1038/437618a

Full Text | PDF (717K)

In brief p619

doi: 10.1038/437619a

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Market watch p619

doi: 10.1038/437619b

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Correspondence

Small groups find fatal purpose through the web p620

Scott Atran and Jessica Stern

doi: 10.1038/437620a

Full Text | PDF (105K)

Most radiation-related deaths happened in 1945 p620

Burton Bennett

doi: 10.1038/437620b

Full Text | PDF (105K)

Public disclosure could deter conflicts of interest p620

Ned Feder

doi: 10.1038/437620c

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Books and Arts

Diversity and controversy p621

Why did a well-intentioned effort to understand human evolution go so wrong?

Diane Paul reviews Race to the Finish: Identity and Governance in an Age of Genomics by Jenny Reardon

doi: 10.1038/437621a

Full Text | PDF (5,990K)

Touching a nerve p622

Charles Stevens reviews The War of the Soups and the Sparks: The Discovery of Neurotransmitters and the Dispute over How Nerves Communicate by Elliot S. Valenstein

doi: 10.1038/437622a

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Roving the Solar System p623

William K. Hartmann reviews The Planets by Dava Sobel

doi: 10.1038/437623a

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Virtual life p623

doi: 10.1038/437623b

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Concepts

Thinking big p625

Fritz London's single-minded thinking led him to surpass even Einstein, as he believed correctly that quantum mechanics was right at all scales, including the macroscopic.

Philip W. Anderson

doi: 10.1038/437625a

Full Text | PDF (140K)

News and Views

Plant biology: A receptor for gibberellin p627

The identification of a receptor for gibberellin, a plant signalling molecule, opens up new prospects for understanding plant growth and development. Not least, crop-selection programmes should benefit.

Dario Bonetta and Peter McCourt

doi: 10.1038/437627a

Full Text | PDF (312K)

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Oceanography: Nutrients in remote mode p628

Phytoplankton productivity depends on the replenishment of nutrients in ocean surface waters. An explanation for a region of strikingly low productivity invokes a little-considered aspect of the nutrient cycle.

Marina Lévy

doi: 10.1038/437628a

Full Text | PDF (1,407K)

Fluid dynamics: Let us spray p629

Richard Webb

doi: 10.1038/437629a

Full Text | PDF (1,331K)

Systems biology: Deviations in mating p631

Why do cells of the same type, grown in the same conditions, look and behave so differently? Studying fluctuations in a well-characterized genetic pathway in yeast hints at how such variation arises.

Avigdor Eldar and Michael Elowitz

doi: 10.1038/437631a

Full Text | PDF (217K)

50 & 100 years ago p632

doi: 10.1038/437632a

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Materials science: Pore show p633

The holes of mesoporous materials provide sheltered venues for many catalytic and adsorbent processes. A complex and beautiful crystalline germanate structure widens the scope of such materials.

Hermann Gies

doi: 10.1038/437633a

Full Text | PDF (194K)

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Obituary: Joseph Rotblat 1908−2005 p634

Physicist who committed his life to the cause of nuclear disarmament.

Sally Milne and Robert Hinde

doi: 10.1038/437634a

Full Text | PDF (134K)

Brief Communications

Rheology: Liquefaction of quicksand under stress p635

A person trapped in salt-lake quicksand is not in any danger of being sucked under completely.

A. Khaldoun, E. Eiser, G. H. Wegdam and Daniel Bonn

doi: 10.1038/437635a

First paragraph | Full Text | PDF (258K)

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Robotics: Self-replication from random parts p636

Saul Griffith, Dan Goldwater and Joseph M. Jacobson

doi: 10.1038/437636a

First paragraph | Full Text | PDF (369K) | Supplementary information

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Articles

Anthropogenic ocean acidification over the twenty-first century and its impact on calcifying organisms p681

James C. Orr, Victoria J. Fabry, Olivier Aumont, Laurent Bopp, Scott C. Doney, Richard A. Feely, Anand Gnanadesikan, Nicolas Gruber, Akio Ishida, Fortunat Joos, Robert M. Key, Keith Lindsay, Ernst Maier-Reimer, Richard Matear, Patrick Monfray, Anne Mouchet, Raymond G. Najjar, Gian-Kasper Plattner, Keith B. Rodgers, Christopher L. Sabine, Jorge L. Sarmiento, Reiner Schlitzer, Richard D. Slater, Ian J. Totterdell, Marie-France Weirig, Yasuhiro Yamanaka and Andrew Yool

doi: 10.1038/nature04095

Abstract | Full Text | PDF (1,041K) | Supplementary information

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The effect of advection on the nutrient reservoir in the North Atlantic subtropical gyre p687

Jaime B. Palter, M. Susan Lozier and Richard T. Barber

doi: 10.1038/nature03969

Abstract | Full Text | PDF (596K) | Supplementary information

GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin p693

Miyako Ueguchi-Tanaka, Motoyuki Ashikari, Masatoshi Nakajima, Hironori Itoh, Etsuko Katoh, Masatomo Kobayashi, Teh-yuan Chow, Yue-ie C. Hsing, Hidemi Kitano, Isomaro Yamaguchi and Makoto Matsuoka

doi: 10.1038/nature04028

Abstract | Full Text | PDF (554K) | Supplementary information

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Regulated cell-to-cell variation in a cell-fate decision system p699

Alejandro Colman-Lerner, Andrew Gordon, Eduard Serra, Tina Chin, Orna Resnekov, Drew Endy, C. Gustavo Pesce and Roger Brent

doi: 10.1038/nature03998

Abstract | Full Text | PDF (598K) | Supplementary information

Letters

Lost and found dark matter in elliptical galaxies p707

A. Dekel, F. Stoehr, G. A. Mamon, T. J. Cox, G. S. Novak and J. R. Primack

doi: 10.1038/nature03970

First paragraph | Full Text | PDF (226K) | Supplementary information

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Isotope-induced partial localization of core electrons in the homonuclear molecule N₂ p711

Daniel Rolles, Markus Braune, Slobodan Cvejanovi, Oliver Gener, Rainer Hentges, Sanja Korica, Burkhard Langer, Toralf Lischke, Georg Prümper, Axel Reinköster, Jens Viefhaus, Björn Zimmermann, Vincent McKoy and Uwe Becker

doi: 10.1038/nature04040

First paragraph | Full Text | PDF (385K)

A mesoporous germanium oxide with crystalline pore walls and its chiral derivative p716

Xiaodong Zou, Tony Conradsson, Miia Klingstedt, Mike S. Dadachov and Michael O'Keeffe

doi: 10.1038/nature04097

First paragraph | Full Text | PDF (430K) | Supplementary information

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Field evidence for surface-wave-induced instability of sand dunes p720

Hicham Elbelrhiti, Philippe Claudin and Bruno Andreotti

doi: 10.1038/nature04058

First paragraph | Full Text | PDF (364K) | Supplementary information

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Trace element signature of subduction-zone fluids, melts and supercritical liquids at 120−180 km depth p724

Ronit Kessel, Max W. Schmidt, Peter Ulmer and Thomas Pettke

doi: 10.1038/nature03971

First paragraph | Full Text | PDF (279K) | Supplementary information

Diatom carbon export enhanced by silicate upwelling in the northeast Atlantic p728

John T. Allen, Louise Brown, Richard Sanders, C. Mark Moore, Alexander Mustard, Sophie Fielding, Mike Lucas, Michel Rixen, Graham Savidge, Stephanie Henson and Dan Mayor

doi: 10.1038/nature03948

First paragraph | Full Text | PDF (768K)

Meniscus-climbing insects p733

David L. Hu and John W. M. Bush

doi: 10.1038/nature03995

First paragraph | Full Text | PDF (279K) | Supplementary information

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Conformity to cultural norms of tool use in chimpanzees p737

Andrew Whiten, Victoria Horner and Frans B. M. de Waal

doi: 10.1038/nature04047

First paragraph | Full Text | PDF (253K) | Supplementary information

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Ca²⁺/calmodulin is critical for brassinosteroid biosynthesis and plant growth p741

Liqun Du and B. W. Poovaiah

doi: 10.1038/nature03973

First paragraph | Full Text | PDF (517K) | Supplementary information

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WntD is a feedback inhibitor of Dorsal/NF-B in Drosophila development and immunity p746

Michael D. Gordon, Marc S. Dionne, David S. Schneider and Roel Nusse

doi: 10.1038/nature04073

First paragraph | Full Text | PDF (315K) | Supplementary information

Interference with AI-2-mediated bacterial cell−cell communication p750

Karina B. Xavier and Bonnie L. Bassler

doi: 10.1038/nature03960

First paragraph | Full Text | PDF (348K) | Supplementary information

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Phosphatidylserine-dependent engulfment by macrophages of nuclei from erythroid precursor cells p754

Hideyuki Yoshida, Kohki Kawane, Masato Koike, Yoshimi Mori, Yasuo Uchiyama and Shigekazu Nagata

doi: 10.1038/nature03964

First paragraph | Full Text | PDF (504K) | Supplementary information

A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR- p759

Gabriel Pascual, Amy L. Fong, Sumito Ogawa, Amir Gamliel, Andrew C. Li, Valentina Perissi, David W. Rose, Timothy M. Willson, Michael G. Rosenfeld and Christopher K. Glass

doi: 10.1038/nature03988

First paragraph | Full Text | PDF (503K) | Supplementary information

Structural basis of West Nile virus neutralization by a therapeutic antibody p764

Grant E. Nybakken, Theodore Oliphant, Syd Johnson, Stephen Burke, Michael S. Diamond and Daved H. Fremont

doi: 10.1038/nature03956

First paragraph | Full Text | PDF (531K) | Supplementary information

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A non-haem iron centre in the transcription factor NorR senses nitric oxide p769

Benoît D'Autréaux, Nicholas P. Tucker, Ray Dixon and Stephen Spiro

doi: 10.1038/nature03953

First paragraph | Full Text | PDF (355K) | Supplementary information

Technology Features

Imaging: The big picture p775

Over the past ten years, microscopy has been transformed from slice, stain and fix, to the capacity to view living cells and even whole organisms in real time. Lisa Melton looks at what's on offer.

Lisa Melton

doi: 10.1038/437775a

Full Text | PDF (434K)

Table of suppliers p780

doi: 10.1038/437780a

| PDF (100K)

Naturejobs

Stemming the tide p783

Stem-cell policies could dictate job flow.

Paul Smaglik

doi:10.1038/nj7059-783a

Full Text | PDF (141K)

Capital attractions p784

Despite funding uncertainties, Berlin's facilities, charisma and cosmopolitan atmosphere continue to draw researchers from across Europe, says Quirin Schiermeier.

Quirin Schiermeier

doi:10.1038/nj7059-784a

Full Text | PDF (739K)

Highlight: Germany

doi:10.1038/nj0090

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Highlight: Ohio

doi:10.1038/nj0091

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Futures

Feeling rejected p788

World beater.

Alastair Reynolds

doi: 10.1038/437788a

Full Text | PDF (196K)