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Nature 437, 656-663 (29 September 2005) | doi:10.1038/nature04164; Published online 28 September 2005
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Review Article Polymer-supported membranes as models of the cell surface
Motomu Tanaka1,2 & Erich Sackmann1
Abstract
Lipid-bilayer membranes supported on solid substrates are widely used as cell-surface models that connect biological and artificial materials. They can be placed either directly on solids or on ultrathin polymer supports that mimic the generic role of the extracellular matrix. The tools of modern genetic engineering and bioorganic chemistry make it possible to couple many types of biomolecule to supported membranes. This results in sophisticated interfaces that can be used to control, organize and study the properties and function of membranes and membrane-associated proteins. Particularly exciting opportunities arise when these systems are coupled with advanced semiconductor technology.
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