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Nature 437, 640-647 (29 September 2005) | doi:10.1038/nature04162; Published online 28 September 2005
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Gastroenterologist
- South Atlanta Medical Clinic, PC (GI Group)
- Atlanta, GA, USA
Postdoctoral Fellow - Computational Genomics - Team 78 – Ref: 80464
- Wellcome Trust Sanger Institute
- Hinxton, Cambridgeshire CB10 1, UK
Review Article Interfaces and the driving force of hydrophobic assembly
David Chandler1
Abstract
The hydrophobic effect — the tendency for oil and water to segregate — is important in diverse phenomena, from the cleaning of laundry, to the creation of micro-emulsions to make new materials, to the assembly of proteins into functional complexes. This effect is multifaceted depending on whether hydrophobic molecules are individually hydrated or driven to assemble into larger structures. Despite the basic principles underlying the hydrophobic effect being qualitatively well understood, only recently have theoretical developments begun to explain and quantify many features of this ubiquitous phenomenon.
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