Supplementary information

From the following article:

Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes

Jin Zhang, Christopher J. Hupfeld, Susan S. Taylor, Jerrold M. Olefsky & Roger Y. Tsien

Nature 437, 569-573(22 September 2005)

doi:10.1038/nature04140

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Supplementary Figures

Supplementary Figures S1-S4, showing effect of insulin treatment on betaAR-associated cAMP generation, effect of insulin treatment on PKA activity in the nucleus, effect of the functionally inactive Ht31p, and a model for insulin modulated compartmentation in adipocytes.

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Supplementary Methods

Additional information about the imaging methods used in this study.

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