Supplementary information
From the following article:
Evolutionary information for specifying a protein fold
Michael Socolich, Steve W. Lockless, William P. Russ, Heather Lee, Kevin H. Gardner & Rama Ranganathan
Nature 437, 512-518(22 September 2005)
doi:10.1038/nature03991
Supplementary Notes
Supplementary Table S1, Supplementary Table S2, Supplementary Methods and Supplementary Figure Legends.
Supplementary Figure S1
Statistical coupling analysis for one site in the WW domain family.
Supplementary Figure S2
Summary of all sequences constructed and experimentally tested.
Supplementary Figure S3
Assessment of expression and solubility of all sequences constructed.
Supplementary Figure S4
Thermal denaturation and renaturation studies.
Supplementary Figure S5
One-dimensional proton NMR spectra for natural WW domains (a), CC sequences (b), and IC sequences (c).
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