Supplementary information
From the following article:
Natural-like function in artificial WW domains
William P. Russ, Drew M. Lowery, Prashant Mishra, Michael B. Yaffe & Rama Ranganathan
Nature 437, 579-583(22 September 2005)
doi:10.1038/nature03990
Supplementary Figure Legends
Text to accompany the below Supplementary Figures.
Supplementary Figure S1
Binding specificity assays determined by the oriented peptide library assay for (a) 28 natural WW domains and (b) 10 artificial WW domains designed using the SCA matrix.
Supplementary Figure S2
Saturation mutagenesis of the peptide ligands for the two major functional classes of WW domains identified.
Supplementary Figure S3
Thermodynamic double mutant cycles in the WW domain Nedd4.3 (N39), measuring the energetic coupling between the T28A mutant and mutants at three other sites within the network of co-evolving residues (L3A, E8A, and H23A).
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