Supplementary information

From the following article:

DNA sequence and analysis of human chromosome 18

Chad Nusbaum, Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Bruno Piqani, Cherylyn L Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakaki & Eric S. Lander

Nature 437, 551-555(22 September 2005)

doi:10.1038/nature03983

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Supplementary Notes

This file contains the Supplementary Methods (including those for mapping, sequencing and annotation; validation of map, sequence and annotation; comparative analysis), Supplementary Data (gene families, overlapping genes, domains, paralogs and potential newly evolving genes) and the Supplementary Discussion of gene density and conservation of non-protein coding sequences. This file also contains additional references.

Supplementary Tables S1-S11

Supplementary Table S1-S11 provide information on: chromosome properties; gaps, clones, genetic markers and radiation hybrid markers on the chromosome 18 path; contributing sequencing centers; gene deserts and disease genes on chromosome 18; randomness of gene distribution by chromosome; gene names and symbols; overlapping genes on chromosome 18.

Supplementary Figures S1-S4

Supplementary Figure S1, the relationship of the finished sequence map to genetic and radiation hybrid maps of chromosome 18. Supplementary Figure S2, an example of gene model extension. Supplementary Figure S3, the relationship between gene density and median intron length. Supplementary Figure S4, Distributions of Z-scores for conserved elements analysis.

Supplementary Figure Legends

Text to accompany the above Supplementary Figures.

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