Editorials

Don't keep your distance p451

Investigations that involve human subjects always require a close relationship between the researchers and those being studied.

doi: 10.1038/437451a

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Value-free nanotech? p451

Efforts to gauge public attitudes to nanotechnology reveal concerns that can be readily addressed.

doi: 10.1038/437451b

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Science after Katrina p452

The hurricane disaster on the Gulf coast will change the federal government's research priorities.

doi: 10.1038/437452a

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Research Highlights

Research highlights p454

doi: 10.1038/437454a

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News

Astronomers reject the term 'planet' p456

Controversial plan would end debate over number of planets in Solar System.

Jim Giles

doi: 10.1038/437456a

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Brain imaging ready to detect terrorists, say neuroscientists p457

MRI scans can pick up lies, but raise ethical issues.

Jennifer Wild

doi: 10.1038/437457a

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Flu researchers slam US agency for hoarding data p458

Better sharing of information would help vaccine design.

Declan Butler

doi: 10.1038/437458a

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Industry money skews drug overviews p458

Meta-analyses gain a positive spin if funded by drug firms.

Jim Giles

doi: 10.1038/437458b

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Hurricane link to climate change is hazy p461

Research may show why storms in different regions respond differently to global warming.

Quirin Schiermeier

doi: 10.1038/437461a

Full Text | PDF (172K)

Lack of lab notes casts doubt on RNA researcher's results p461

Japanese university has been unable to confirm its professor's results.

Ichiko Fuyuno

doi: 10.1038/437461b

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After Katrina: tracking the toxic flood p462

Gulf mission assesses state of wildlife and fish stocks.

Adrianne Appel

doi: 10.1038/437462a

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Race claims spark fury over Croatia's school curriculum p463

Minister claims DNA shows Croats are only distantly related to other Slavs.

Alison Abbott

doi: 10.1038/437463a

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Sidelines p463

doi: 10.1038/437463b

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News in brief p465

doi: 10.1038/437465a

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News Features

Hurricane Katrina: Left behind p467

Two researchers survived the worst of Hurricane Katrina, caring for sick patients in a flooded hospital. Erika Check hears of their harrowing experience.

doi: 10.1038/437467a

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Atmospheric science: Inside information p468

Earth's climate depends strongly on clouds. But what really goes on within these layered structures? Heike Langenberg reports on two satellites that aim to find out.

doi: 10.1038/437468a

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See also: Editor's summary

Back to school p470

This month, as most researchers gear up to teach, two scientists are heading into the classroom to learn. Geoff Brumfiel asks why a physicist would want to enrol in biology lessons.

doi: 10.1038/437470a

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Conservation policy: Fishy futures p473

George Sugihara has gone from an academic career in biological oceanography to the world of high finance, and back again. Now he is applying the lessons he learned in business to the conservation of fish stocks. Rex Dalton reports.

doi: 10.1038/437473a

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Business

Swooping for biotech p475

Big pharmaceutical companies are moving swiftly to acquire biotechnology companies — especially if they can snap them up on the cheap. Meredith Wadman reports.

Meredith Wadman

doi: 10.1038/437475a

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Correspondence

Re-wilding: no need for exotics as natives return p476

Eric Dinerstein and W. Robert Irvin

doi: 10.1038/437476a

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Re-wilding: don't overlook humans living on the plains p476

Steven Shay

doi: 10.1038/437476b

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How synthetic biology can avoid GMO-style conflicts p476

Mark Tepfer

doi: 10.1038/437476c

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Chiropractors start major study of spinal outcomes p476

Barry Lewis

doi: 10.1038/437476d

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Commentary

A universal register for animal names p477

Andrew Polaszek and colleagues propose an open-access web-register for animal names, which they believe is vital to move taxonomy into the twenty-first century.

doi: 10.1038/437477a

Full Text | PDF (98K) | Supplementary information

See also: Editor's summary

Books and Arts

Coping with interesting times p479

Unless we take action urgently, climate change could spell disaster for a wide range of living species.

Paul Colinvaux reviews Climate Change and Biodiversity

doi: 10.1038/437479a

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A path through the forest p480

Jeffry S. Isaacson reviews Nerve Endings: The Discovery of the Synapse by Richard Rapport

doi: 10.1038/437480a

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New in paperback p480

doi: 10.1038/437480b

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An ill-defined idea? p481

Andrew Scull reviews Lovers and Livers: Disease Concepts in History by Jacalyn Duffin

doi: 10.1038/437481a

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Science in culture p482

William Hunter at the Royal Academy of Arts.

Martin Kemp

doi: 10.1038/437482a

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News and Views

Environmental science: The carbon cycle under stress p483

In the summer of 2003, Europe experienced an exceptionally hot and dry spell. That 'natural experiment' prompted a continental-scale analysis of how terrestrial ecosystems respond to such climatic extremes.

Dennis Baldocchi

doi: 10.1038/437483a

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Structural biology: Origins of chemical biodefence p484

The idea that complex biological systems can evolve through a series of simple, random events is not universally accepted. The structure of a vital immune protein shows how such evolution can occur at a molecular level.

Robert Liddington and Laurie Bankston

doi: 10.1038/437484a

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Earth science: Unleaded high-performance p485

Previous measurements of uranium-series isotopes have implied uncomfortably fast speeds of melt movement through the mantle. Yet the latest results suggest such velocities were serious underestimates.

Tim Elliott

doi: 10.1038/437485a

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Structural biology: Form and function instructions p486

How much and what kind of information is required to fold a chain of amino acids into a functioning protein? It seems the problem may not be as daunting as once thought — the solution is in the coevolution data.

Jeffery W. Kelly

doi: 10.1038/437486a

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Synthetic chemistry: Recipes for excess p487

The selective production of a particular mirror-image form of a molecule is immensely important to organic synthesis. But techniques to find the right catalysts have traditionally been protracted and fiddly. Help is at hand.

John Hartwig

doi: 10.1038/437487a

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Techniques: Imaging at a distance p488

Magnetic resonance imaging is often limited by the need to encode information and acquire the resonance signals in less-than-ideal locations. Performing these two steps at different places provides a solution.

Siegfried Stapf

doi: 10.1038/437488a

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News and Views Feature

Pharmaceuticals: A new grammar for drug discovery p491

To realize the potential of the genome for identifying candidate drugs we must move beyond individual genes and proteins. The signalling pathways in cells provide the right level for such analyses.

Mark C. Fishman and Jeffery A. Porter

doi: 10.1038/437491a

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Brief Communications

Ecology: 'Devil's gardens' bedevilled by ants p495

An ant species uses herbicidal weaponry to secure its own niche in the Amazonian rainforest.

Megan E. Frederickson, Michael J. Greene and Deborah M. Gordon

doi: 10.1038/437495a

First paragraph | Full Text | PDF (360K) | Supplementary information

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Climate modelling: Northern Hemisphere circulation p496

Nathan P. Gillett

doi: 10.1038/437496a

First paragraph | Full Text | PDF (133K)

Brief Communications Arising

Human cooperation: Second-order free-riding problem solved? pE8

James H. Fowler

doi: 10.1038/nature04201

First paragraph | Full Text | PDF (67K)

Human cooperation: Second-order free-riding problem solved? (reply) pE8

Karthik Panchanathan and Rob Boyd

doi: 10.1038/nature04202

First paragraph | Full Text | PDF (75K)

Review

Pathophysiological consequences of VEGF-induced vascular permeability p497

Sara M. Weis and David A. Cheresh

doi: 10.1038/nature03987

Abstract | Full Text | PDF (437K)

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Articles

Structures of complement component C3 provide insights into the function and evolution of immunity p505

Bert J. C. Janssen, Eric G. Huizinga, Hans C. A. Raaijmakers, Anja Roos, Mohamed R. Daha, Kristina Nilsson-Ekdahl, Bo Nilsson and Piet Gros

doi: 10.1038/nature04005

Abstract | Full Text | PDF (709K) | Supplementary information

See also: Editor's summary | News and Views by Liddington & Bankston

Evolutionary information for specifying a protein fold p512

Michael Socolich, Steve W. Lockless, William P. Russ, Heather Lee, Kevin H. Gardner and Rama Ranganathan

doi: 10.1038/nature03991

Abstract | Full Text | PDF (544K) | Supplementary information

See also: Editor's summary | News and Views by Kelly

Letters

A large population of galaxies 9 to 12 billion years back in the history of the Universe p519

O. Le Fèvre, S. Paltani, S. Arnouts, S. Charlot, S. Foucaud, O. Ilbert, H. J. McCracken, G. Zamorani, D. Bottini, B. Garilli, V. Le Brun, D. Maccagni, J. P. Picat, R. Scaramella, M. Scodeggio, L. Tresse, G. Vettolani, A. Zanichelli, C. Adami, S. Bardelli, M. Bolzonella, A. Cappi, P. Ciliegi, T. Contini, P. Franzetti, I. Gavignaud, L. Guzzo, A. Iovino, B. Marano, C. Marinoni, A. Mazure, B. Meneux, R. Merighi, R. Pellò, A. Pollo, L. Pozzetti, M. Radovich, E. Zucca, M. Arnaboldi, M. Bondi, A. Bongiorno, G. Busarello, L. Gregorini, F. Lamareille, G. Mathez, Y. Mellier, P. Merluzzi, V. Ripepi and D. Rizzo

doi: 10.1038/nature03979

First paragraph | Full Text | PDF (396K)

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An organic thyristor p522

F. Sawano, I. Terasaki, H. Mori, T. Mori, M. Watanabe, N. Ikeda, Y. Nogami and Y. Noda

doi: 10.1038/nature04087

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Optical isotropy and iridescence in a smectic 'blue phase' p525

Jun Yamamoto, Isa Nishiyama, Miyoshi Inoue and Hiroshi Yokoyama

doi: 10.1038/nature04034

First paragraph | Full Text | PDF (422K) | Supplementary information

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Europe-wide reduction in primary productivity caused by the heat and drought in 2003 p529

Ph. Ciais, M. Reichstein, N. Viovy, A. Granier, J. Ogée, V. Allard, M. Aubinet, N. Buchmann, Chr. Bernhofer, A. Carrara, F. Chevallier, N. De Noblet, A. D. Friend, P. Friedlingstein, T. Grünwald, B. Heinesch, P. Keronen, A. Knohl, G. Krinner, D. Loustau, G. Manca, G. Matteucci, F. Miglietta, J. M. Ourcival, D. Papale, K. Pilegaard, S. Rambal, G. Seufert, J. F. Soussana, M. J. Sanz, E. D. Schulze, T. Vesala and R. Valentini

doi: 10.1038/nature03972

First paragraph | Full Text | PDF (475K) | Supplementary information

See also: Editor's summary | News and Views by Baldocchi

Minimum speed limit for ocean ridge magmatism from ²¹⁰Pb−²²⁶Ra−²³⁰Th disequilibria p534

K. H. Rubin, I. van der Zander, M. C. Smith and E. C. Bergmanis

doi: 10.1038/nature03993

First paragraph | Full Text | PDF (301K) | Supplementary information

See also: News and Views by Elliott

Variations in earthquake-size distribution across different stress regimes p539

Danijel Schorlemmer, Stefan Wiemer and Max Wyss

doi: 10.1038/nature04094

First paragraph | Full Text | PDF (291K)

Isolation of an autotrophic ammonia-oxidizing marine archaeon p543

Martin Könneke, Anne E. Bernhard, José R. de la Torre, Christopher B. Walker, John B. Waterbury and David A. Stahl

doi: 10.1038/nature03911

First paragraph | Full Text | PDF (290K) | Supplementary information

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Endangered plants persist under phosphorus limitation p547

Martin J. Wassen, Harry Olde Venterink, Elena D. Lapshina and Franziska Tanneberger

doi: 10.1038/nature03950

First paragraph | Full Text | PDF (273K) | Supplementary information

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DNA sequence and analysis of human chromosome 18 p551

Chad Nusbaum, Michael C. Zody, Mark L. Borowsky, Michael Kamal, Chinnappa D. Kodira, Todd D. Taylor, Charles A. Whittaker, Jean L. Chang, Christina A. Cuomo, Ken Dewar, Michael G. FitzGerald, Xiaoping Yang, Amr Abouelleil, Nicole R. Allen, Scott Anderson, Toby Bloom, Boris Bugalter, Jonathan Butler, April Cook, David DeCaprio, Reinhard Engels, Manuel Garber, Andreas Gnirke, Nabil Hafez, Jennifer L. Hall, Catherine Hosage Norman, Takehiko Itoh, David B. Jaffe, Yoko Kuroki, Jessica Lehoczky, Annie Lui, Pendexter Macdonald, Evan Mauceli, Tarjei S. Mikkelsen, Jerome W. Naylor, Robert Nicol, Cindy Nguyen, Hideki Noguchi, Sinéad B. O'Leary, Bruno Piqani, Cherylyn L Smith, Jessica A. Talamas, Kerri Topham, Yasushi Totoki, Atsushi Toyoda, Hester M. Wain, Sarah K. Young, Qiandong Zeng, Andrew R. Zimmer, Asao Fujiyama, Masahira Hattori, Bruce W. Birren, Yoshiyuki Sakaki and Eric S. Lander

doi: 10.1038/nature03983

First paragraph | Full Text | PDF (277K) | Supplementary information

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A role for lateral hypothalamic orexin neurons in reward seeking p556

Glenda C. Harris, Mathieu Wimmer and Gary Aston-Jones

doi: 10.1038/nature04071

First paragraph | Full Text | PDF (296K) | Supplementary information

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Dependence of Drosophila wing imaginal disc cytonemes on Decapentaplegic p560

Frank Hsiung, Felipe-Andrès Ramirez-Weber, D. David Iwaki and Thomas B. Kornberg

doi: 10.1038/nature03951

First paragraph | Full Text | PDF (325K) | Supplementary information

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation p564

Ignacio Varela, Juan Cadiñanos, Alberto M. Pendás, Ana Gutiérrez-Fernández, Alicia R. Folgueras, Luis M. Sánchez, Zhongjun Zhou, Francisco J. Rodríguez, Colin L. Stewart, José A Vega, Karl Tryggvason, José M. P. Freije and Carlos López-Otín

doi: 10.1038/nature04019

First paragraph | Full Text | PDF (497K) | Supplementary information

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Insulin disrupts -adrenergic signalling to protein kinase A in adipocytes p569

Jin Zhang, Christopher J. Hupfeld, Susan S. Taylor, Jerrold M. Olefsky and Roger Y. Tsien

doi: 10.1038/nature04140

First paragraph | Full Text | PDF (365K) | Supplementary information

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways p574

Kimberly L. Dodge-Kafka, Joseph Soughayer, Genevieve C. Pare, Jennifer J. Carlisle Michel, Lorene K. Langeberg, Michael S. Kapiloff and John D. Scott

doi: 10.1038/nature03966

First paragraph | Full Text | PDF (550K) | Supplementary information

Natural-like function in artificial WW domains p579

William P. Russ, Drew M. Lowery, Prashant Mishra, Michael B. Yaffe and Rama Ranganathan

doi: 10.1038/nature03990

First paragraph | Full Text | PDF (979K) | Supplementary information

See also: Editor's summary | News and Views by Kelly

Crystal structure of the RNA component of bacterial ribonuclease P p584

Alfredo Torres-Larios, Kerren K. Swinger, Andrey S. Krasilnikov, Tao Pan and Alfonso Mondragón

doi: 10.1038/nature04074

First paragraph | Full Text | PDF (4.6M) | Supplementary information

Naturejobs

An infinite learning curve p589

More scientists seek formal training beyond the PhD — for both on- and off-the bench skills.

Paul Smaglik

doi:10.1038/nj7058-589a

Full Text | PDF (119K)

Tag teams p590

A collaboration can produce powerful results when everyone pulls together, but if you go about it the wrong way, or with the wrong people, it may all fall down around you. Kendall Powell finds out how to choose the right partners.

Kendall Powell

doi:10.1038/nj7058-590a

Full Text | PDF (324K)

Stanley Plotkin, board of directors, Dynavax, Berkeley, California p592

Academic Epidemiologist moves into industrial vaccinology.

Virginia Gewin

doi:10.1038/nj7058-592a

Full Text | PDF (96K)

Scientists & Societies p592

Training series for women scientists expands.

Geraldine Richmond

doi:10.1038/nj7058-592b

Full Text | PDF (96K)

Graduate journal: Back-up plans p592

Graduate student learns the importance of back-ups — the hard way.

Jason Underwood

doi:10.1038/nj7058-592c

Full Text | PDF (96K)

Futures

Falling p594

The view from here.

Benjamin Rosenbaum

doi: 10.1038/437594a

Full Text | PDF (171K)