Access
To read this story in full you will need to login or make a payment (see right).
Review
Nature 437, 497-504 (22 September 2005) | doi:10.1038/nature03987
Open Innovation Challenges
-
Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
-
Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
- More Challenges
- Powered by:
nature jobs
Faculty Positions
- University of Delhi
- Delhi, India
PhD
- Universitatsmedizin Gottingen
- Gottingen 37099 Deutschland
Pathophysiological consequences of VEGF-induced vascular permeability
Sara M. Weis1 & David A. Cheresh1
Abstract
Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and ischaemic disease has unexpected pathophysiological consequences. By uncoupling endothelial cell–cell junctions VEGF causes vascular permeability and oedema, resulting in extensive injury to ischaemic tissues after stroke or myocardial infarction. In cancer, VEGF-mediated disruption of the vascular barrier may potentiate tumour cell extravasation, leading to widespread metastatic disease. Therefore, by blocking the vascular permeability promoting effects of VEGF it may be feasible to reduce tissue injury after ischaemic disease and minimize the invasive properties of circulating tumour cells.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Robo4 counteracts VEGF signalingNature Medicine News and Views (01 Apr 2008)
Leaky vessels? Call Ang1!Nature Medicine News and Views (01 Feb 2000)
See all 4 matches for News And ViewsRESEARCH
VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherinNature Cell Biology Article (01 Nov 2006)
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditionsNature Medicine Article (01 May 2001)
See all 38 matches for Research