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Nature 437, 484-485 (22 September 2005) | doi:10.1038/437484a; Published online 21 September 2005
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Structural biology: Origins of chemical biodefence
Robert Liddington1 & Laurie Bankston1
Abstract
The idea that complex biological systems can evolve through a series of simple, random events is not universally accepted. The structure of a vital immune protein shows how such evolution can occur at a molecular level.
Before antibodies evolved, primitive multicellular organisms devised a general defence system against bacterial and viral invaders called 'innate immunity'. The system has survived in vertebrates with its core components little changed during the intervening 700 million years1.
- Robert Liddington and Laurie Bankston are at the Infectious and Inflammatory Disease Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA.
Email: rlidding@burnham.org
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RESEARCH
Structure of C3b in complex with CRIg gives insights into regulation of complement activationNature Letters to Editor (09 Nov 2006)
Structures of complement component C3 provide insights into the function and evolution of immunityNature Article (22 Sep 2005)
