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From the following article:

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

Ignacio Varela, Juan Cadiñanos, Alberto M. Pendás, Ana Gutiérrez-Fernández, Alicia R. Folgueras, Luis M. Sánchez, Zhongjun Zhou, Francisco J. Rodríguez, Colin L. Stewart, José A Vega, Karl Tryggvason, José M. P. Freije & Carlos López-Otín

Nature 437, 564-568(22 September 2005)

doi:10.1038/nature04019

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Figure 1

Activation of a p53-induced pathway as a result of Zmpste24 or Lmna deficiencies.

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Figure 2

Senescence in Zmpste24-/- mice

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Figure 3

Lmna heterozygosity rescues the Zmpste24-/- phenotype.

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Figure 4

Partial recovery of the Zmpste24-/- phenotype in a p53-null background.

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