Supplementary information

From the following article:

Genome sequencing in microfabricated high-density picolitre reactors

Marcel Margulies, Michael Egholm, William E. Altman, Said Attiya, Joel S. Bader, Lisa A. Bemben, Jan Berka, Michael S. Braverman, Yi-Ju Chen, Zhoutao Chen, Scott B. Dewell, Lei Du, Joseph M. Fierro, Xavier V. Gomes, Brian C. Godwin, Wen He, Scott Helgesen, Chun He Ho, Gerard P. Irzyk, Szilveszter C. Jando, Maria L. I. Alenquer, Thomas P. Jarvie, Kshama B. Jirage, Jong-Bum Kim, James R. Knight, Janna R. Lanza, John H. Leamon, Steven M. Lefkowitz, Ming Lei, Jing Li, Kenton L. Lohman, Hong Lu, Vinod B. Makhijani, Keith E. McDade, Michael P. McKenna, Eugene W. Myers, Elizabeth Nickerson, John R. Nobile, Ramona Plant, Bernard P. Puc, Michael T. Ronan, George T. Roth, Gary J. Sarkis, Jan Fredrik Simons, John W. Simpson, Maithreyan Srinivasan, Karrie R. Tartaro, Alexander Tomasz, Kari A. Vogt, Greg A. Volkmer, Shally H. Wang, Yong Wang, Michael P. Weiner, Pengguang Yu, Richard F. Begley & Jonathan M. Rothberg

Nature 437, 376-380(15 September 2005)

doi:10.1038/nature03959

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Supplementary Figures

This file contains Supplementary Figures S1-S11 that illustrate various experimental, data processing and modelling results pertinent to the sequencing technology described in the paper.

Supplementary Tables

This file includes Supplementary Tables S1-S4 with model results and sequencing statistics for a number of runs performed with the instrument described in the paper.

Supplementary Methods

This file includes detailed methods and materials for the sequencing technology described in the paper, and detailed description of data processing and bioinformatics algorithms. Earlier errors (see Corrigendum in Nature 441, page 120; 4 May 2006) have been corrected and are shown in red.

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