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Nature 437, 197-198 (8 September 2005) | doi:10.1038/437197a; Published online 7 September 2005

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Structural biology: Fibres hinge on swapped domains

Andrew D. Miranker1

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When proteins assemble themselves into fibres, there can be grave pathological consequences. Designing an otherwise soluble protein to make fibres provides a general mechanism for the construction process.

DNA encodes RNA, which encodes protein — this 'central dogma', coined by Francis Crick in 1958, underpins modern molecular biology1. Implicit in this formula is the tenet that a linear chain of amino acids contains the complete instructions to form a three-dimensional protein structure.

  1. Andrew D. Miranker is in the Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Avenue, New Haven, Connecticut 06520-8114, USA.
    Email: Andrew.Miranker@yale.edu

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