Supplementary information

From the following article:

A genome-wide comparison of recent chimpanzee and human segmental duplications

Ze Cheng, Mario Ventura, Xinwei She, Philipp Khaitovich, Tina Graves, Kazutoyo Osoegawa, Deanna Church, Pieter DeJong, Richard K. Wilson, Svante Pääbo, Mariano Rocchi & Evan E. Eichler

Nature 437, 88-93(1 September 2005)

doi:10.1038/nature04000

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Supplementary Methods

Additional description of the methods used in this study.

Supplementary Figure Legends

Text to accompany the below Supplementary Figures.

Supplementary Figures

This file contains Supplementary Figures S1-S6, S8.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 1. (See chimpparalogy.gs.washington.edu)

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 2.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 3.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 4.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 5.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 6.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 7.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 8.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 9.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 10.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 11.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 12.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 13.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 14.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 15.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 16.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 17.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 18.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 19.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 20.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 21.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome 22.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, chromosome X.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, Chimpanzee Sequence Y.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, Chimpanzee Sequence, PTR Chr22.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, Chimpanzee Sequence, PTR Specific Sequence.

Supplementary Figure S7

Chromosome views of chimpanzee and human segmental duplications, Chimpanzee Sequence, Unaligned PTR Sequence.

Supplementary Table S1

Comparison of human and chimpanzee WSSD duplications

Supplementary Table S2

WSSD duplications and triallelic variants

Supplementary Table S3

FISH results for shared (CH) duplications

Supplementary Table S4

Chimpanzee-human array CGH vs. chimpanzee WSSD duplications

Supplementary Table S5

cDNA/ESTs with copy number verification from Fortna, A. et al.

Supplementary Table S6

Duplication statistics and duplication shadowing simulation results

Supplementary Table S7

Human specific gene duplications

Supplementary Table S8

Chimpanzee specific gene duplications

Supplementary Table S9

Genes differentially expressed and specifically duplicated in human or chimpanzee

Supplementary Table S10

Differentially expressed genes between human and chimpanzee vs. duplication regions

Supplementary Table S11

FISH results with chimpanzee-only duplications.

Supplementary Table S12

FISH results with chimpanzee-only duplications.

Supplementary Table S13

Human and chimpanzee single nucleotide variation in unique regions and duplication/unique transition regions.

Supplementary Table S14

Sequence identity of shared vs. human-only duplications

Supplementary Table S15

Regions where human copy # exceeds chimp copy# by >5

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