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Progress
Nature 437, 64-67 (1 September 2005) | doi:10.1038/nature04103
Open Innovation Challenges
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Direct Molecular Detection of Proteins and Nucleic Acids
This Challenge is looking for novel approaches to protein and nucleic acid detection. This is an Id...
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Optimizing Sub-cellular Localization Tags
The Seeker is looking for methods to optimize sub-cellular localization tags for protein expression....
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Faculty Position in Mathematical Biology
- The Ohio State University
- Ohio, USA
Academic Surgical Pathologists
- Northwestern University
- Chicago, Illinois, USA
Molecular insights into human brain evolution
Robert Sean Hill1 & Christopher A. Walsh1
Abstract
Rapidly advancing knowledge of genome structure and sequence enables new means for the analysis of specific DNA changes associated with the differences between the human brain and that of other mammals. Recent studies implicate evolutionary changes in messenger RNA and protein expression levels, as well as DNA changes that alter amino acid sequences. We can anticipate having a systematic catalogue of DNA changes in the lineage leading to humans, but an ongoing challenge will be relating these changes to the anatomical and functional differences between our brain and that of our ancient and more recent ancestors.
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NEWS AND VIEWS
Evolutionary biology Human brain gene wins genome raceNature News and Views (14 Sep 2006)

