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Nature 437, 45-46 (1 September 2005) | doi:10.1038/437045a; Published online 31 August 2005
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Phytochemistry: Ibuprofen-like activity in extra-virgin olive oil
Gary K. Beauchamp1, Russell S. J. Keast1,4, Diane Morel2, Jianming Lin5, Jana Pika5, Qiang Han3, Chi-Ho Lee1,4, Amos B. Smith1,3 & Paul A. S. Breslin1
Abstract
Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil.
Abstract
Newly pressed extra-virgin olive oil contains oleocanthal — a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen1. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
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RESEARCH
Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trialEuropean Journal of Clinical Nutrition Scientific Correspondence
