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Nature 436, 946-952 (18 August 2005) | doi:10.1038/nature04079; Published online 17 August 2005

review article Adaptive immune responses in acute and chronic hepatitis C virus infection

David G. Bowen1 & Christopher M. Walker1,2

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The hepatitis C virus (HCV) persists in the majority of infected individuals and is a significant cause of human illness and death globally. Recent studies have yielded important insights into immunity to HCV, in particular revealing the central role of T cells in viral control and clearance. Other key features of adaptive immune responses remain obscure, including mechanisms by which T cells control HCV replication, the role of antibodies in conferring protection and how cellular and humoral immunity are subverted in persistent infection.

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