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Nature 436, 933-938 (18 August 2005) | doi:10.1038/nature04077; Published online 17 August 2005
Open Innovation Challenges
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Efficient Chromosome Doubling: Plant Cell Division
The Seeker is looking for an efficient chromosome doubling method in plants and in particular, metho...
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Structural & Computational Biology
- Indian Institute of Chemical Biology
- Kolkata India
Systems and Cellular Neuroscientists
- University of Texas at Dallas
- Dallas, Texas, United States
review article Unravelling hepatitis C virus replication from genome to function
Brett D. Lindenbach1 & Charles M. Rice1
Abstract
Since the discovery of the hepatitis C virus over 15 years ago, scientists have raced to develop diagnostics, study the virus and find new therapies. Yet virtually every attempt to dissect this pathogen has met with roadblocks that impeded progress. Its replication was restricted to humans or experimentally infected chimpanzees, and efficient growth of the virus in cell culture failed until very recently. Nevertheless hard-fought progress has been made and the first wave of antiviral drugs is entering clinical trials.
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