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Nature 436, 925 (18 August 2005) | doi:10.1038/436925a; Published online 17 August 2005

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Cardiology:  Rips repaired

Richard A. Steinhardt1

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In Duchenne muscular dystrophy, muscle cells die as a result of suffering many tiny membrane ruptures. A compound that increases membrane resealing can protect heart muscle cells from these effects.

Degenerative muscle diseases are usually the result of defects in the cytoskeleton, the cell's internal scaffolding. This structure normally shields muscle cells from mechanical stress, protecting their membranes from tearing.

  1. Richard A. Steinhardt is in the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA.
    Email: ricksteinhardt@berkeley.edu

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Nature Medicine News and Views (01 Aug 2005)