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Nature 436, 922-923 (18 August 2005) | doi:10.1038/436922a; Published online 17 August 2005
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Cell biology: Shaggy mouse tales
Elizabeth H. Blackburn1
Abstract
First impressions can be misleading. The enzyme telomerase has been well studied because of its initial association with cell ageing processes and cancer — but it now seems that this is not all it can do.
The way in which a biological entity is first identified can limit perceptions of the full range of its functions. The telomerase enzyme, for instance, was originally discovered on the basis of its vital ability to lengthen telomeres — the stretches of non-coding DNA at the ends of chromosomes.
- Elizabeth H. Blackburn is in the Department of Biochemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143-2200, USA.
Email: telomer@itsa.ucsf.edu
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