FIGURE 2. Examples of inhibitors of the HCV RNA-dependent RNA polymerase.
From the following article:
Challenges and successes in developing new therapies for hepatitis C
Raffaele De Francesco and Giovanni Migliaccio
Nature 436, 953-960 (18 August 2005)
doi:10.1038/nature04080
a, Structures of 2'-C-methyl-nucleosides. NM283 is a valine ester of NM107. b, Structures of representative examples of different classes of non-nucleoside inhibitors of the NS5B polymerase, each presumably binding at a different allosteric site on the enzyme: benzimidazoles, benzothiadiazines and thiophenes.
