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Nature 436, 787-789 (11 August 2005) | doi:10.1038/436787a; Published online 10 August 2005
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Assoc. Scientific Manager / Scientific Manager - Biopharmaceutics
- Syngene International
- Bangalore, Karnataka 560099 India
Faculty Positions in Systems Neuroscience
- NYU School of Medicine
- Smilow Research Center
Cancer: Two in one
Anton Berns1
Abstract
As cancer develops, at least two cell processes are disrupted — cell growth is promoted, and cell death inhibited. It seems that mutated versions of the notorious cancer-promoting protein MYC can accomplish both at once.
The MYC gene is one of the classic cancer-promoting 'oncogenes'. It is overexpressed in many types of tumour, and the MYC protein it encodes causes a surge in the proliferation of cells.
- Anton Berns is in the Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Email: a.berns@nki.nl
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RESEARCH
Evasion of the p53 tumour surveillance network by tumour-derived MYC mutantsNature Article (11 Aug 2005)
Probing tumor phenotypes using stable and regulated synthetic microRNA precursorsNature Genetics Technical Report (01 Nov 2005)
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