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Nature 436, 787-789 (11 August 2005) | doi:10.1038/436787a; Published online 10 August 2005
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Assistant Professor and Associate Professor
- Massachusetts General Hospital/ Harvard Medical School
- Charlestown, MA
Gastroenterologist
- Wayne State University
- Detroit, Michigan, USA
Cancer: Two in one
Anton Berns1
Abstract
As cancer develops, at least two cell processes are disrupted — cell growth is promoted, and cell death inhibited. It seems that mutated versions of the notorious cancer-promoting protein MYC can accomplish both at once.
The MYC gene is one of the classic cancer-promoting 'oncogenes'. It is overexpressed in many types of tumour, and the MYC protein it encodes causes a surge in the proliferation of cells.
- Anton Berns is in the Division of Molecular Genetics and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Email: a.berns@nki.nl
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