Supplementary information
From the following article:
Oncogene-induced senescence as an initial barrier in lymphoma development
Melanie Braig, Soyoung Lee, Christoph Loddenkemper, Cornelia Rudolph, Antoine H.F.M. Peters, Brigitte Schlegelberger, Harald Stein, Bernd Dörken, Thomas Jenuwein & Clemens A. Schmitt
Nature 436, 660-665(4 August 2005)
doi:10.1038/nature03841
Supplementary Figure S1
Characterization of Ras-induced neoplasms.
Supplementary Figure S2
Representative dual-colour flow cytometric analyses of the indicated antigens reflecting the haematopoietic differentiation status in different haematopoietic compartments of Suv39h1+/+ and Suv39h1-/- mice of matched age.
Supplementary Figure S3
Invasiveness, growth characteristics and expression of related genes in mouse embryo fibroblasts and Ras-driven lymphomas.
Supplementary Figure S4
Characterization of TSA/DAC-promoted lymphoma and leukaemia in E
-N-Ras transgenic mice.
Supplementary Table S1
Clinical and pathological characteristics of terminal disease conditions in E-N-Ras mice of the indicated genotypes grouped according to their time-to-death.
Supplementary Table S2
Comprehensive summary of haematological differentiation measured in nucleated cell populations isolated from the indicated compartments of Suv39h1+/+ and Suv39h1-/- mice.
Supplementary Table S3
Chromosomal aberrations of individual primary control (n = 2), Suv39h1-null (n = 4), and p53-null Ras-lymphomas (n = 3) assessed by spectral karyotyping.
Supplementary Notes
Legends for Figures S1-S4 and Tables S1-S3
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