TY - JOUR AU - Campisi, J. TI - Cellular senescence as a tumour-suppressor mechanism JA - Trends Cell Biol. PY - 2001/// VL - 11 SP - S27 EP - S31 PB - Nature Publishing Group M3 - 10.1016/S0962-8924(01)02151-1 N1 - 10.1016/S0962-8924(01)02151-1 UR - http://dx.doi.org/10.1016/S0962-8924(01)02151-1 ER - TY - JOUR AU - Schmitt, C. A. TI - Senescence, apoptosis and therapy[mdash]cutting the lifelines of cancer JA - Nature Rev. Cancer PY - 2003/// VL - 3 SP - 286 EP - 295 PB - Nature Publishing Group M3 - 10.1038/nrc1044 N1 - 10.1038/nrc1044 UR - http://dx.doi.org/10.1038/nrc1044 ER - TY - JOUR AU - Serrano, M. AU - Lin, A. W. AU - McCurrach, M. E. AU - Beach, D. AU - Lowe, S. W. TI - Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a JA - Cell PY - 1997/// VL - 88 SP - 593 EP - 602 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(00)81902-9 N1 - 10.1016/S0092-8674(00)81902-9 UR - http://dx.doi.org/10.1016/S0092-8674(00)81902-9 ER - TY - JOUR AU - Trimarchi, J. M. AU - Lees, J. A. TI - Sibling rivalry in the E2F family JA - Nature Rev. Mol. Cell Biol. PY - 2002/// VL - 3 SP - 11 EP - 20 PB - Nature Publishing Group M3 - 10.1038/nrm714 N1 - 10.1038/nrm714 UR - http://dx.doi.org/10.1038/nrm714 ER - TY - JOUR AU - Narita, M. TI - Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence JA - Cell PY - 2003/// VL - 113 SP - 703 EP - 716 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(03)00401-X N1 - 10.1016/S0092-8674(03)00401-X UR - http://dx.doi.org/10.1016/S0092-8674(03)00401-X ER - TY - JOUR AU - Rea, S. TI - Regulation of chromatin structure by site-specific histone H3 methyltransferases JA - Nature PY - 2000/// VL - 406 SP - 593 EP - 599 PB - Nature Publishing Group M3 - 10.1038/35020506 N1 - 10.1038/35020506 UR - http://dx.doi.org/10.1038/35020506 ER - TY - JOUR AU - Nielsen, S. J. TI - Rb targets histone H3 methylation and HP1 to promoters JA - Nature PY - 2001/// VL - 412 SP - 561 EP - 565 PB - Nature Publishing Group M3 - 10.1038/35087620 N1 - 10.1038/35087620 UR - http://dx.doi.org/10.1038/35087620 ER - TY - JOUR AU - Bannister, A. J. TI - Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain JA - Nature PY - 2001/// VL - 410 SP - 120 EP - 124 PB - Nature Publishing Group M3 - 10.1038/35065138 N1 - 10.1038/35065138 UR - http://dx.doi.org/10.1038/35065138 ER - TY - JOUR AU - Lachner, M. AU - O'Carroll, D. AU - Rea, S. AU - Mechtler, K. AU - Jenuwein, T. TI - Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins JA - Nature PY - 2001/// VL - 410 SP - 116 EP - 120 PB - Nature Publishing Group M3 - 10.1038/35065132 N1 - 10.1038/35065132 UR - http://dx.doi.org/10.1038/35065132 ER - TY - JOUR AU - Ait-Si-Ali, S. TI - A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells JA - EMBO J. PY - 2004/// VL - 23 SP - 605 EP - 615 PB - Nature Publishing Group M3 - 10.1038/sj.emboj.7600074 N1 - 10.1038/sj.emboj.7600074 UR - http://dx.doi.org/10.1038/sj.emboj.7600074 ER - TY - JOUR AU - Haupt, Y. AU - Harris, A. W. AU - Adams, J. M. TI - Retroviral infection accelerates T lymphomagenesis in E mu-N-ras transgenic mice by activating c-myc or N-myc JA - Oncogene PY - 1992/// VL - 7 SP - 981 EP - 986 PB - Nature Publishing Group ER - TY - JOUR AU - Peters, A. H. TI - Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability JA - Cell PY - 2001/// VL - 107 SP - 323 EP - 337 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(01)00542-6 N1 - 10.1016/S0092-8674(01)00542-6 UR - http://dx.doi.org/10.1016/S0092-8674(01)00542-6 ER - TY - JOUR AU - Kemp, C. J. AU - Donehower, L. A. AU - Bradley, A. AU - Balmain, A. TI - Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors JA - Cell PY - 1993/// VL - 74 SP - 813 EP - 822 PB - Nature Publishing Group M3 - 10.1016/0092-8674(93)90461-X N1 - 10.1016/0092-8674(93)90461-X UR - http://dx.doi.org/10.1016/0092-8674(93)90461-X ER - TY - JOUR AU - Lin, A. W. TI - Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signalling JA - Genes Dev. PY - 1998/// VL - 12 SP - 3008 EP - 3019 PB - Nature Publishing Group ER - TY - JOUR AU - Lyon, M. F. TI - Gene action in the X-chromosome of the mouse (Mus musculus L.) JA - Nature PY - 1961/// VL - 190 SP - 372 EP - 373 PB - Nature Publishing Group M3 - 10.1038/190372a0 N1 - 10.1038/190372a0 UR - http://dx.doi.org/10.1038/190372a0 ER - TY - JOUR AU - Ohtani, N. TI - Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence JA - Nature PY - 2001/// VL - 409 SP - 1067 EP - 1070 PB - Nature Publishing Group M3 - 10.1038/35059131 N1 - 10.1038/35059131 UR - http://dx.doi.org/10.1038/35059131 ER - TY - JOUR AU - Chang, B. D. TI - A senescence-like phenotype distinguishes tumour cells that undergo terminal proliferation arrest after exposure to anticancer agents JA - Cancer Res. PY - 1999/// VL - 59 SP - 3761 EP - 3767 PB - Nature Publishing Group ER - TY - JOUR AU - Schmitt, C. A. TI - A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy JA - Cell PY - 2002/// VL - 109 SP - 335 EP - 346 PB - Nature Publishing Group M3 - 10.1016/S0092-8674(02)00734-1 N1 - 10.1016/S0092-8674(02)00734-1 UR - http://dx.doi.org/10.1016/S0092-8674(02)00734-1 ER - TY - JOUR AU - Dimri, G. P. TI - A biomarker that identifies senescent human cells in culture and in aging skin in vivo JA - Proc. Natl Acad. Sci. USA PY - 1995/// VL - 92 SP - 9363 EP - 9367 PB - Nature Publishing Group M3 - 10.1073/pnas.92.20.9363 N1 - 10.1073/pnas.92.20.9363 UR - http://dx.doi.org/10.1073/pnas.92.20.9363 ER - TY - JOUR AU - Nguyen, C. T. TI - Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2[prime]-deoxycytidine JA - Cancer Res. PY - 2002/// VL - 62 SP - 6456 EP - 6461 PB - Nature Publishing Group ER - TY - JOUR AU - Fuks, F. AU - Hurd, P. J. AU - Deplus, R. AU - Kouzarides, T. TI - The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase JA - Nucleic Acids Res. PY - 2003/// VL - 31 SP - 2305 EP - 2312 PB - Nature Publishing Group M3 - 10.1093/nar/gkg332 N1 - 10.1093/nar/gkg332 UR - http://dx.doi.org/10.1093/nar/gkg332 ER - TY - JOUR AU - Leone, G. AU - Voso, M. T. AU - Teofili, L. AU - Lubbert, M. TI - Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS JA - Clin. Immunol. PY - 2003/// VL - 109 SP - 89 EP - 102 PB - Nature Publishing Group M3 - 10.1016/S1521-6616(03)00207-9 N1 - 10.1016/S1521-6616(03)00207-9 UR - http://dx.doi.org/10.1016/S1521-6616(03)00207-9 ER - TY - JOUR AU - Rane, S. G. AU - Cosenza, S. C. AU - Mettus, R. V. AU - Reddy, E. P. TI - Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence JA - Mol. Cell. Biol. PY - 2002/// VL - 22 SP - 644 EP - 656 PB - Nature Publishing Group M3 - 10.1128/MCB.22.2.644-656.2002 N1 - 10.1128/MCB.22.2.644-656.2002 UR - http://dx.doi.org/10.1128/MCB.22.2.644-656.2002 ER - TY - JOUR AU - Guerra, C. TI - Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context JA - Cancer Cell PY - 2003/// VL - 4 SP - 111 EP - 120 PB - Nature Publishing Group M3 - 10.1016/S1535-6108(03)00191-0 N1 - 10.1016/S1535-6108(03)00191-0 UR - http://dx.doi.org/10.1016/S1535-6108(03)00191-0 ER - TY - JOUR AU - Tuveson, D. A. TI - Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects JA - Cancer Cell PY - 2004/// VL - 5 SP - 375 EP - 387 PB - Nature Publishing Group M3 - 10.1016/S1535-6108(04)00085-6 N1 - 10.1016/S1535-6108(04)00085-6 UR - http://dx.doi.org/10.1016/S1535-6108(04)00085-6 ER - TY - JOUR AU - Kim, K. C. AU - Geng, L. AU - Huang, S. TI - Inactivation of a histone methyltransferase by mutations in human cancers JA - Cancer Res. PY - 2003/// VL - 63 SP - 7619 EP - 7623 PB - Nature Publishing Group ER - TY - JOUR AU - Steele-Perkins, G. TI - Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily JA - Genes Dev. PY - 2001/// VL - 15 SP - 2250 EP - 2262 PB - Nature Publishing Group M3 - 10.1101/gad.870101 N1 - 10.1101/gad.870101 UR - http://dx.doi.org/10.1101/gad.870101 ER - TY - JOUR AU - Schmitt, C. A. AU - McCurrach, M. E. AU - de Stanchina, E. AU - Wallace-Brodeur, R. R. AU - Lowe, S. W. TI - INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53 JA - Genes Dev. PY - 1999/// VL - 13 SP - 2670 EP - 2677 PB - Nature Publishing Group M3 - 10.1101/gad.13.20.2670 N1 - 10.1101/gad.13.20.2670 UR - http://dx.doi.org/10.1101/gad.13.20.2670 ER - TY - JOUR AU - Schmitt, C. A. TI - Dissecting p53 tumour suppressor functions in vivo JA - Cancer Cell PY - 2002/// VL - 1 SP - 289 EP - 298 PB - Nature Publishing Group M3 - 10.1016/S1535-6108(02)00047-8 N1 - 10.1016/S1535-6108(02)00047-8 UR - http://dx.doi.org/10.1016/S1535-6108(02)00047-8 ER - TY - JOUR AU - Frank, O. TI - Tumor cells escape suicide gene therapy by genetic and epigenetic instability JA - Blood PY - 2004/// VL - 104 SP - 3543 EP - 3549 PB - Nature Publishing Group M3 - 10.1182/blood-2004-03-0852 N1 - 10.1182/blood-2004-03-0852 UR - http://dx.doi.org/10.1182/blood-2004-03-0852 ER - TY - JOUR AU - Hamrouni, A. AU - Aublin, A. AU - Guillaume, P. AU - Maryanski, J. L. TI - T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires JA - J. Exp. Med. PY - 2003/// VL - 197 SP - 601 EP - 614 PB - Nature Publishing Group M3 - 10.1084/jem.20021945 N1 - 10.1084/jem.20021945 UR - http://dx.doi.org/10.1084/jem.20021945 ER -