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Nature 436, 725-730 (4 August 2005) | doi:10.1038/nature03918;
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- National Institute of Mental Health (NIMH)
- Bethesda, Maryland
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- Northeastern University
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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Cellular senescence has been theorized to oppose neoplastic transformation triggered by activation of oncogenic pathways in vitro, but the relevance of senescence in vivo has not been established. The PTEN and p53 tumour suppressors are among the most commonly inactivated or mutated genes in human cancer including prostate cancer.
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