Access
To read this story in full you will need to login or make a payment (see right).
Brief Communications
Nature 436, 642 (4 August 2005) | doi:10.1038/436642a
Open Innovation Challenges
-
Novel Approaches to Protecting Maize from Insect Damage
The Seeker is looking for novel approaches to protecting maize from insect damage. This Challenge re...
-
Methods of Modeling Adaptation in Populations
The analysis of adaptation with a population is a frequently encountered computational modeling scen...
- More Challenges
- Powered by:
nature jobs
Junior Research Groups (W1 / W2)
- Cluster of Excellence "Multimodal Computing and Interaction"
- Saarbruecken Germany
PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Tumour biology: Senescence in premalignant tumours
Manuel Collado1, Jesús Gil2, Alejo Efeyan1, Carmen Guerra1, Alberto J. Schuhmacher1, Marta Barradas1, Alberto Benguría3, Angel Zaballos3, Juana M. Flores4, Mariano Barbacid1, David Beach5 & Manuel Serrano1
Abstract
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development1, 2, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.
To read this story in full you will need to login or make a payment (see right).
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Senescence comes of ageNature Medicine News and Views (01 Sep 2005)
Barriers to Ras transformationNature Cell Biology News and Views (01 May 2007)
RESEARCH
Differential regulation of telomerase activity and telomerase RNA during multi-stage tumorigenesisNature Genetics Letter (01 Feb 1996)
See all 15 matches for Research