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Brief Communications

Nature 436, 641 (4 August 2005) | doi:10.1038/436641a; Published online 3 August 2005

There is a Corrigendum (25 August 2005) associated with this document.

There is a Corrigendum (9 March 2006) associated with this document.

There is a Brief Communications Arising (9 March 2006) associated with this document.

There is a Brief Communications Arising (9 March 2006) associated with this document.

There is a Corrigendum (12 October 2006) associated with this document.

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Dogs cloned from adult somatic cells

Byeong Chun Lee1, Min Kyu Kim1, Goo Jang1, Hyun Ju Oh1, Fibrianto Yuda1, Hye Jin Kim1, M. Hossein Shamim1, Jung Ju Kim1, Sung Keun Kang1, Gerald Schatten2 & Woo Suk Hwang1

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Several mammals — including sheep, mice, cows, goats, pigs, rabbits, cats1, a mule2, a horse3 and a litter of three rats4 — have been cloned by transfer of a nucleus from a somatic cell into an egg cell (oocyte) that has had its nucleus removed. This technology has not so far been successful in dogs because of the difficulty of maturing canine oocytes in vitro. Here we describe the cloning of two Afghan hounds by nuclear transfer from adult skin cells into oocytes that had matured in vivo. Together with detailed sequence information generated by the canine-genome project5, 6, the ability to clone dogs by somatic-cell nuclear transfer should help to determine genetic and environmental contributions to the diverse biological and behavioural traits associated with the many different canine breeds7, 8.

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RESEARCH

Molecular genetics Verification that Snuppy is a clone

Nature Brief Communication (09 Mar 2006)

Corrigendum

Nature Brief Communication (09 Mar 2006)

Molecular genetics DNA analysis of a putative dog clone

Nature Brief Communication (09 Mar 2006)

Corrigendum

Nature Brief Communication (25 Aug 2005)