Figures and Tables

From the following article:

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Zhenbang Chen, Lloyd C. Trotman, David Shaffer, Hui-Kuan Lin, Zohar A. Dotan, Masaru Niki, Jason A. Koutcher, Howard I. Scher, Thomas Ludwig, William Gerald, Carlos Cordon-Cardo & Pier Paolo Pandolfi

Nature 436, 725-730(4 August 2005)

doi:10.1038/nature03918

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Figure 1 - Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.com

Figure 1

Loss of Trp53 does not initiate prostate tumours but renders Pten-deficient carcinomas lethal.

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Figure 2

Acute loss of Pten triggers the p53-dependent senescence pathway in primary mouse embryonic fibroblasts (MEFs).

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Figure 3

Acute loss of Pten results in ARF upregulation and p53/p21 stabilization in primary MEFs.

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Figure 4

The p53-dependent cellular senescence pathway restricts tumorigenesis in Pten-deficient prostates.

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