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Nature 436, 473-474 (28 July 2005) | doi:10.1038/436473a; Published online 27 July 2005
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Neuroscience: Genomics reaches the synapse
Cori Bargmann1
Abstract
A genomic survey uses innovative genetics to make neurons susceptible to RNA-mediated gene inactivation. The results implicate many genes in communication at the synapse between neurons and muscle.
RNA interference (RNAi) is a spectacularly useful technique for selectively reducing gene activity — and thereby garnering clues about gene function1. In this issue, a collaborative group of geneticists, genomicists and neuroscientists report the first large-scale RNAi screen in neuroscience (Sieburth et al.page 510)2.
- Cori Bargmann is at the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.
Email: cori@rockefeller.edu
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