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Nature 436, 181-182 (14 July 2005) | doi:10.1038/436181a; Published online 13 July 2005
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Developmental biology: Tiny brakes for a growing heart
Benoit G. Bruneau1
Abstract
The discovery of microRNAs has revolutionized many areas of biology. The latest news is that these RNAs seem to regulate the crucial balance between growth and specialization of cardiac cells.
MicroRNAs (miRNAs for short) are tiny RNA molecules that downregulate protein production, either by inhibiting the translation of protein from messenger RNA or by promoting the degradation of mRNA1, 2. In plants, miRNAs have major influences on embryonic development, primarily by slowing down the production of proteins that regulate gene expression.
- Benoit G. Bruneau is in the Department of Cardiovascular Research and Developmental Biology, The Hospital for Sick Children, and the Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario M5G 1X8, Canada.
Email: bbruneau@sickkids.ca
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