Figures and Tables
From the following article:
Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1
Jürgen Besemer, Hanna Harant, Shirley Wang, Berndt Oberhauser, Katharina Marquardt, Carolyn A. Foster, Erwin P. Schreiner, Jan E. de Vries, Christiane Dascher-Nadel & Ivan J. D. Lindley
Nature 436, 290-293(14 July 2005)
doi:10.1038/nature03670
Figure 1
CAM741 dose-dependently inhibits VCAM1 glycoprotein expression in transiently transfected cells.
Full size figure and legend (63K)
Figure 2
Overexpressed VCAM1 is degraded by intracellular proteases in the presence of CAM741.
Full size figure and legend (39K)
Figure 3
CAM741 dose-dependently inhibits cotranslational translocation of VCAM1.
Full size figure and legend (63K)
Figure 4
VCAM1 SP is crucial for conferring cyclopeptolide sensitivity.
Full size figure and legend (90K)
Figure 5
CAM741 inhibits VCAM1 translocation at a post-targeting step and enhances interaction of the VCAM1 nascent chains with Sec61
.