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Nature 436, 33-35 (7 July 2005) | doi:10.1038/436033a; Published online 6 July 2005
Cancer biology: The weakest link?
Glenn Merlino1
Abstract
Cellular lineages are defined by master regulatory proteins that dictate their fate and ensure their survival. The dependence on such factors of tumours that are resistant to treatment may prove to be their Achilles' heel.
The pigment-producing cells in the skin — melanocytes — have a master regulator called MITF (for 'microphthalmia-associated transcription factor'). This factor is required for committing immature cells to the melanocyte lineage during development and is intimately involved in decisions regarding cell survival, growth and specialization (differentiation).
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